Impact of deuterium substitution on the pharmacokinetics of pharmaceuticals

EM Russak, EM Bednarczyk - Annals of Pharmacotherapy, 2019 - journals.sagepub.com
Objective: Stable heavy isotopes of hydrogen, carbon, and other elements have been
incorporated into drug molecules, largely as tracers for quantitation during the drug …

Dextromethorphan-bupropion for the treatment of depression: a systematic review of efficacy and safety in clinical trials

D Akbar, TG Rhee, F Ceban, R Ho, KM Teopiz, B Cao… - CNS drugs, 2023 - Springer
Background A significant proportion of adults with major depressive disorder (MDD) do not
respond to treatments which are currently used in clinical practice such as first-generation …

Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences

TM Carbonaro, MW Johnson, E Hurwitz… - Psychopharmacology, 2018 - Springer
Rationale Although psilocybin and dextromethorphan (DXM) are hallucinogens, they have
different receptor mechanisms of action and have not been directly compared. Objective …

Novel antidepressant drugs: Beyond monoamine targets

X Gonda, P Dome, JC Neill, FI Tarazi - CNS spectrums, 2023 - cambridge.org
Treatment of major depressive disorder (MDD) including treatment-resistant depression
(TRD) remains a major unmet need. Although there are several classes of dissimilar …

Analgesic alkaloids derived from traditional Chinese medicine in pain management

W Jiang, M Tang, L Yang, X Zhao, J Gao… - Frontiers in …, 2022 - frontiersin.org
Chronic pain is one of the most prevalent health problems. The establishment of chronic
pain is complex. Current medication for chronic pain mainly dependent on anticonvulsants …

Marine natural products, multitarget therapy and repurposed agents in Alzheimer's disease

M Martins, R Silva, M MM Pinto, E Sousa - Pharmaceuticals, 2020 - mdpi.com
Alzheimer's disease (AD) is a multifactorial disease characterized by the presence of
amyloid plaques, neurofibrillary tangles, and nerve cell death that affects, mainly, older …

Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice

A Amador, CD Bostick, H Olson, J Peters, CR Camp… - Brain, 2020 - academic.oup.com
NMDA receptors play crucial roles in excitatory synaptic transmission. Rare variants in
GRIN2A encoding the GluN2A subunit are associated with a spectrum of disorders, ranging …

Expanding role of NMDA receptor antagonists in the management of pain

D Kreutzwiser, QA Tawfic - Cns Drugs, 2019 - Springer
Pain management is complex regardless of whether the pain is acute or chronic in nature or
non-cancer or cancer related. In addition, relatively few pain pharmacotherapy options with …

Clinical pharmacology, toxicity, and abuse potential of opioids

D Vearrier, O Grundmann - The Journal of Clinical …, 2021 - Wiley Online Library
Opioids were the most common drug class resulting in overdose deaths in the United States
in 2019. Widespread clinical use of prescription opioids for moderate to severe pain …

Targeting sigma receptors for the treatment of neurodegenerative and neurodevelopmental disorders

DS Malar, P Thitilertdecha, KS Ruckvongacheep… - CNS drugs, 2023 - Springer
The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …