[HTML][HTML] The TNF family of ligands and receptors: communication modules in the immune system and beyond

C Dostert, M Grusdat, E Letellier… - Physiological …, 2018 - journals.physiology.org
The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …

A brief history of T cell help to B cells

S Crotty - Nature Reviews Immunology, 2015 - nature.com
In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the
history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize …

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

P Revy, T Muto, Y Levy, F Geissmann, A Plebani… - Cell, 2000 - cell.com
The activation-induced cytidine deaminase (AID) gene, specifically expressed in germinal
center B cells in mice, is a member of the cytidine deaminase family. We herein report …

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

T Kawabe, T Naka, K Yoshida, T Tanaka, H Fujiwara… - Immunity, 1994 - Elsevier
An engagement of CD40 with CD40 ligand (CD40L) expressed on activated T cells is known
to provide an essential costimulatory signal to B cells in vitro. To investigate the role of CD40 …

Activation of human dendritic cells through CD40 cross-linking.

C Caux, C Massacrier, B Vanbervliet… - The Journal of …, 1994 - rupress.org
Dendritic cells, the professional antigen-presenting cells (APC) involved in T cell priming,
express CD40, a molecule which triggering plays a key role in B cell growth and …

Clinical spectrum of X-linked hyper-IgM syndrome

J Levy, T Espanol-Boren, C Thomas, A Fischer… - The Journal of …, 1997 - Elsevier
We report the clinical and immunologic features and outcome in 56 patients with X-linked
hyper-IgM syndrome, a disorder caused by mutations in the CD40 ligand gene. Upper and …

The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients

JA Winkelstein, MC Marino, H Ochs, R Fuleihan… - Medicine, 2003 - journals.lww.com
The X-linked hyper-IgM (XHIGM) syndrome is an uncommon primary immunodeficiency
disease caused by mutations in the gene for CD40 ligand and characterized by normal or …

Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response

M Wykes, A Pombo, C Jenkins… - The Journal of …, 1998 - journals.aai.org
Dendritic cells (DC) are thought to initiate Ab synthesis by activation of T cells, which then
provide cytokine and cell-bound “help” to B cells. Here, we provide evidence that DC can …

Induction of human IgE synthesis in B cells by mast cells and basophils

JF Gauchat, S Henchoz, G Mazzei, JP Aubry, T Brunner… - Nature, 1993 - nature.com
IMMUNOGLOBULIN E (IgE) is central to the induction of allergic diseases through its
binding to the high-affinity receptor (FcɛRl) on mast cells and basophils. Crosslinking by …

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

TM Foy, JD Laman, JA Ledbetter, A Aruffo… - The Journal of …, 1994 - rupress.org
gp39, the ligand for CD40 expressed on activated CD4+ T helper cells, is required for the
generation of antibody responses to T-dependent (TD) antigens. Treatment of mice with anti …