S Crotty - Nature Reviews Immunology, 2015 - nature.com
In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize …
The activation-induced cytidine deaminase (AID) gene, specifically expressed in germinal center B cells in mice, is a member of the cytidine deaminase family. We herein report …
T Kawabe, T Naka, K Yoshida, T Tanaka, H Fujiwara… - Immunity, 1994 - Elsevier
An engagement of CD40 with CD40 ligand (CD40L) expressed on activated T cells is known to provide an essential costimulatory signal to B cells in vitro. To investigate the role of CD40 …
C Caux, C Massacrier, B Vanbervliet… - The Journal of …, 1994 - rupress.org
Dendritic cells, the professional antigen-presenting cells (APC) involved in T cell priming, express CD40, a molecule which triggering plays a key role in B cell growth and …
J Levy, T Espanol-Boren, C Thomas, A Fischer… - The Journal of …, 1997 - Elsevier
We report the clinical and immunologic features and outcome in 56 patients with X-linked hyper-IgM syndrome, a disorder caused by mutations in the CD40 ligand gene. Upper and …
JA Winkelstein, MC Marino, H Ochs, R Fuleihan… - Medicine, 2003 - journals.lww.com
The X-linked hyper-IgM (XHIGM) syndrome is an uncommon primary immunodeficiency disease caused by mutations in the gene for CD40 ligand and characterized by normal or …
M Wykes, A Pombo, C Jenkins… - The Journal of …, 1998 - journals.aai.org
Dendritic cells (DC) are thought to initiate Ab synthesis by activation of T cells, which then provide cytokine and cell-bound “help” to B cells. Here, we provide evidence that DC can …
JF Gauchat, S Henchoz, G Mazzei, JP Aubry, T Brunner… - Nature, 1993 - nature.com
IMMUNOGLOBULIN E (IgE) is central to the induction of allergic diseases through its binding to the high-affinity receptor (FcɛRl) on mast cells and basophils. Crosslinking by …
TM Foy, JD Laman, JA Ledbetter, A Aruffo… - The Journal of …, 1994 - rupress.org
gp39, the ligand for CD40 expressed on activated CD4+ T helper cells, is required for the generation of antibody responses to T-dependent (TD) antigens. Treatment of mice with anti …