The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …

Purpose For many patients, the multiple sclerosis (MS) diagnostic process can be lengthy,
costly, and fraught with error. Recent research aims to address the unmet need for an …

Vascular endothelial cells express glycoprotein 130 (gp130), which is utilized as a signaling
receptor by cytokines in the interleukin-6 (IL-6) family. Several IL-6 family cytokines can be …

Abstract Interleukin (IL)-27, a member of the IL-6/IL-12 family, has an important role in
modulating inflammation in partnership with innate and adaptive immune cells. IL-27 …

Background & aims In our previous study, a Seesaw model was proposed for the fluctuation
of crucial anti-(IL-10) and pro-inflammatory (Il-6 & IL-17A) cytokines through vitamin D3. In …

Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at
chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of …

Cytokines are implicated in the immunopathogenesis of multiple sclerosis (MS). Interleukin
(IL)-33, one of the recently discovered members of the IL-1 superfamily, is a dual functional …

Background: In recent investigations addressing neurodegenerative diseases, especially
multiple sclerosis (MS), the roles of brain-derived neurotrophic factor (BDNF) and interleukin …

Objectives Pro‐and anti‐inflammatory properties have been attributed to interleukin‐27 (IL‐
27). Nevertheless, the impact of this cytokine on chronic inflammatory diseases such as …

Abstract IL-23 and IL-27 are believed to be involved in the pathogenesis of Guillain-Barré
syndrome (GBS). However, changes in these cytokines during the dynamic pathological and …