Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes

M Kerkhofs, M Bittremieux, G Morciano, C Giorgi… - Cell death & …, 2018 - nature.com
Inter-organellar communication often takes the form of Ca2+ signals. These Ca2+ signals
originate from the endoplasmic reticulum (ER) and regulate different cellular processes like …

The role of TRPC1 in modulating cancer progression

OM Elzamzamy, R Penner, LA Hazlehurst - Cells, 2020 - mdpi.com
Calcium ions (Ca2+) play an important role as second messengers in regulating a plethora
of physiological and pathological processes, including the progression of cancer. Several …

Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

RS D'Souza, JY Lim, A Turgut, K Servage, J Zhang… - Elife, 2020 - elifesciences.org
Coordinated assembly and disassembly of integrin-mediated focal adhesions (FAs) is
essential for cell migration. Many studies have shown that FA disassembly requires Ca2+ …

Orai1 Ca2+ channel modulators as therapeutic tools for treating cancer: Emerging evidence!

O Mignen, JP Vannier, P Schneider… - Biochemical …, 2024 - Elsevier
In non-excitable cells, Orai proteins represent the main channel for Store-Operated Calcium
Entry (SOCE), and also mediate various store-independent Calcium Entry (SICE) pathways …

Metals and metastasis: exploiting the role of metals in cancer metastasis to develop novel anti-metastatic agents

L Fouani, SV Menezes, M Paulson… - Pharmacological …, 2017 - Elsevier
Metastasis is currently the leading cause of cancer related death and is the most feared and
difficult to treat outcome for cancer patients. This complex process is regulated by a plethora …

Store-Operated Ca2+ Entry in Tumor Progression: From Molecular Mechanisms to Clinical Implications

YF Chen, PC Lin, YM Yeh, LH Chen, MR Shen - Cancers, 2019 - mdpi.com
The remodeling of Ca2+ homeostasis has been implicated as a critical event in driving
malignant phenotypes, such as tumor cell proliferation, motility, and metastasis. Store …

Targeting Intracellular Calcium Signaling ([Ca2+]i) to Overcome Acquired Multidrug Resistance of Cancer Cells: A Mini-Overview

D Büsselberg, AM Florea - Cancers, 2017 - mdpi.com
Cancer is a main public health problem all over the world. It affects millions of humans no
matter their age, gender, education, or social status. Although chemotherapy is the main …

[HTML][HTML] Unmasking amending roles of hypocalcemia in cancer, COVID-19, and sepsis: Engineered nanodelivery and diagnosis

E Ghafouri, M Bigdeli, A Khalafiyan, Z Amirkhani… - Environmental …, 2023 - Elsevier
Abstract Calcium (Ca 2+) homeostasis is crucial for maintaining physiological processes in
the body, and disruptions in Ca 2+ signaling can lead to various pathological conditions …

Targeting Stim and Orai proteins as an alternative approach in anticancer therapy

F Moccia, E Zuccolo, V Poletto, I Turin… - Current medicinal …, 2016 - ingentaconnect.com
An increase in intracellular Ca2+ concentration plays a key role in the establishment of
many cancer hallmarks, including aberrant proliferation, migration, invasion, resistance to …

[HTML][HTML] Calcium remodeling in colorectal cancer

C Villalobos, D Sobradillo… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Colorectal cancer (CRC) is the third most frequent form of cancer and the fourth leading
cause of cancer-related death in the world. Basic and clinical data indicate that aspirin and …