Brain manganese and the balance between essential roles and neurotoxicity

RC Balachandran, S Mukhopadhyay, D McBride… - Journal of Biological …, 2020 - ASBMB
Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …

Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms

M Gade, N Comfort, DB Re - Environmental research, 2021 - Elsevier
The heavy metals lead (Pb), mercury (Hg), and cadmium (Cd) are ubiquitous environmental
pollutants and are known to exert severe adverse impacts on the nervous system even at …

Environmental exposure to low-level lead (Pb) co-occurring with other neurotoxicants in early life and neurodevelopment of children.

JG Dórea - Environmental Research, 2019 - Elsevier
Lead (Pb) is a worldwide environmental contaminant that even at low levels influences brain
development and affects neurobehavior later in life; nevertheless it is only a small fraction of …

Consequences of disturbing manganese homeostasis

J Baj, W Flieger, A Barbachowska, B Kowalska… - International Journal of …, 2023 - mdpi.com
Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …

Prenatal co-exposure to neurotoxic metals and neurodevelopment in preschool children: The Environment and Childhood (INMA) Project

C Freire, E Amaya, F Gil, MF Fernández… - Science of the Total …, 2018 - Elsevier
We sought to determine whether prenatal co-exposure to As, Cd, Hg, Mn, and Pb was
associated with impaired neurodevelopment in preschool children from the Spanish …

[HTML][HTML] Combined effects of lead and manganese on locomotor activity and microbiota in zebrafish

Y Xia, C Wang, X Zhang, J Li, Z Li, J Zhu, Q Zhou… - Ecotoxicology and …, 2023 - Elsevier
Exposure to lead (Pb) and manganese (Mn) during early life influences neurodevelopment
and increases the risk of neurodegenerative disorders. However, the level of developmental …

Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis

W Liu, Y Xin, Q Li, Y Shang, Z Ping, J Min… - Environmental …, 2020 - Springer
Background Although prior studies showed a correlation between environmental
manganese (Mn) exposure and neurodevelopmental disorders in children, the results have …

[HTML][HTML] Exposure to multiple pesticides and neurobehavioral outcomes among smallholder farmers in Uganda

S Fuhrimann, A Farnham, P Staudacher… - Environment …, 2021 - Elsevier
Background Multiple epidemiological studies have shown that exposure to single pesticide
active ingredients or chemical groups is associated with adverse neurobehavioral outcomes …

[HTML][HTML] Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior

MK Horton, L Hsu, BC Henn, A Margolis, C Austin… - Environment …, 2018 - Elsevier
Background Metal exposure alters neurodevelopmental outcomes; little is known about
critical windows of susceptibility when exposure exerts the strongest effect. Objective To …

Manganese in drinking water and cognitive abilities and behavior at 10 years of age: a prospective cohort study

SM Rahman, M Kippler, F Tofail, S Bölte… - Environmental …, 2017 - ehp.niehs.nih.gov
Background: Cross-sectional studies have indicated impaired neurodevelopment with
elevated drinking water manganese concentrations (W-Mn), but potential susceptible …