Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

[HTML][HTML] The intersection of obesity and (long) COVID-19: Hypoxia, thrombotic inflammation, and vascular endothelial injury

M Xiang, X Wu, H Jing, VA Novakovic… - Frontiers in …, 2023 - frontiersin.org
The role of hypoxia, vascular endothelial injury, and thrombotic inflammation in worsening
COVID-19 symptoms has been generally recognized. Damaged vascular endothelium plays …

[HTML][HTML] Good practice statements for antithrombotic therapy in the management of COVID‐19: guidance from the SSC of the ISTH

AC Spyropoulos, JM Connors, JD Douketis… - Journal of Thrombosis …, 2022 - Elsevier
Despite the emergence of high quality randomized trial data with the use of antithrombotic
agents to reduce the risk of thromboembolism, end‐organ failure, and possibly mortality in …

COVID-19-associated pulmonary embolism: review of the pathophysiology, epidemiology, prevention, diagnosis, and treatment

L Ortega-Paz, AH Talasaz… - … in thrombosis and …, 2022 - thieme-connect.com
COVID-19 is associated with endothelial activation in the setting of a potent inflammatory
reaction and a hypercoagulable state. The end result of this thromboinflammatory state is an …

Thrombotic Complications in Children with COVID-19 and MIS-C

R Kumar, MJ Rivkin, L Raffini - Journal of Thrombosis and Haemostasis, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) associated coagulopathy is multifactorial
and involves inflammation driven hypercoagulability, endothelial dysfunction, platelet …

Practical recommendations for optimal thromboprophylaxis in patients with COVID-19: a consensus statement based on available clinical trials

KG Kyriakoulis, E Dimakakos, IG Kyriakoulis… - Journal of Clinical …, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) has been shown to be strongly associated with
increased risk for venous thromboembolism events (VTE) mainly in the inpatient but also in …

[HTML][HTML] Immuno-thrombotic complications of COVID-19: implications for timing of surgery and anticoagulation

CM Bunch, EE Moore, HB Moore, MD Neal… - Frontiers in …, 2022 - frontiersin.org
Early in the coronavirus disease 2019 (COVID-19) pandemic, global governing bodies
prioritized transmissibility-based precautions and hospital capacity as the foundation for …

Anticoagulation in hospitalized patients with COVID-19

L Baumann Kreuziger, M Sholzberg… - Blood, The Journal of …, 2022 - ashpublications.org
Abstract Coronavirus disease-19 (COVID-19) includes a thromboinflammatory syndrome
that may manifest with microvascular and macrovascular thrombosis. Patients with COVID …

The impact of platelets on pulmonary microcirculation throughout COVID-19 and its persistent activating factors

M Xiang, X Wu, H Jing, L Liu, C Wang, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Patients with COVID-19 often have hypoxemia, impaired lung function, and abnormal
imaging manifestations in acute and convalescent stages. Alveolar inflammation, pulmonary …

Emerging clinical trial designs may accelerate translation in hematology: lessons from COVID-19

MD Neal, PR Lawler, R Zarychanski - Blood Advances, 2022 - ashpublications.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the
COVID-19 pandemic in 2020 created unprecedented global challenges to existing models …