Is euchromatin really open in the cell?
Genomic DNA is wrapped around a core histone octamer and forms a nucleosome. In
higher eukaryotic cells, strings of nucleosomes are irregularly folded as chromatin domains …
higher eukaryotic cells, strings of nucleosomes are irregularly folded as chromatin domains …
Chromosome territories
Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief
statement, the possible contribution of nuclear architecture studies to the field of …
statement, the possible contribution of nuclear architecture studies to the field of …
Condensed but liquid-like domain organization of active chromatin regions in living human cells
In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …
domains, for various cellular functions. However, their physical nature in living cells remains …
ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells
HD Ou, S Phan, TJ Deerinck, A Thor, MH Ellisman… - Science, 2017 - science.org
INTRODUCTION In human cells, 2 m of DNA are compacted in the nucleus through
assembly with histones and other proteins into chromatin structures, megabase three …
assembly with histones and other proteins into chromatin structures, megabase three …
Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler
While nuclear compartmentalization is an essential feature of three-dimensional genome
organization, no genomic method exists for measuring chromosome distances to defined …
organization, no genomic method exists for measuring chromosome distances to defined …
Chromosome territories, nuclear architecture and gene regulation in mammalian cells
The expression of genes is regulated at many levels. Perhaps the area in which least is
known is how nuclear organization influences gene expression. Studies of higher-order …
known is how nuclear organization influences gene expression. Studies of higher-order …
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with …
MJ Hendzel, Y Wei, MA Mancini, A Van Hooser… - Chromosoma, 1997 - Springer
We have generated and characterized a novel site-specific antibody highly specific for the
phosphorylated form of the amino-terminus of histone H3 (Ser10). In this study, we used this …
phosphorylated form of the amino-terminus of histone H3 (Ser10). In this study, we used this …
Histone–GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells
Background: The amplification of oncogenes in cancer cells is often mediated by paired
acentric chromatin bodies called double minute chromosomes (DMs), which can accumulate …
acentric chromatin bodies called double minute chromosomes (DMs), which can accumulate …
Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures
C Naughton, N Avlonitis, S Corless… - Nature structural & …, 2013 - nature.com
DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating
gene expression and DNA replication. However, DNA supercoiling at a genomic scale in …
gene expression and DNA replication. However, DNA supercoiling at a genomic scale in …
Single nucleosome imaging reveals loose genome chromatin networks via active RNA polymerase II
Although chromatin organization and dynamics play a critical role in gene transcription, how
they interplay remains unclear. To approach this issue, we investigated genome-wide …
they interplay remains unclear. To approach this issue, we investigated genome-wide …