[HTML][HTML] Cytotoxic CD4+ T cells in cancer: expanding the immune effector toolbox
DY Oh, L Fong - Immunity, 2021 - cell.com
Cytotoxic T cells are important effectors of anti-tumor immunity. While tumor killing is
ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra …
ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra …
Mechanisms of immune activation and regulation: lessons from melanoma
Melanoma, a skin cancer that develops from pigment cells, has been studied intensively,
particularly in terms of the immune response to tumours, and has been used as a model for …
particularly in terms of the immune response to tumours, and has been used as a model for …
[HTML][HTML] Diminished efficacy of programmed death-(ligand) 1 inhibition in STK11-and KEAP1-mutant lung adenocarcinoma is affected by KRAS mutation status
Introduction STK11 and KEAP1 mutations (STK11 mutant [STK11 MUT] and KEAP1 MUT)
are among the most often mutated genes in lung adenocarcinoma (LUAD). Although STK11 …
are among the most often mutated genes in lung adenocarcinoma (LUAD). Although STK11 …
[HTML][HTML] Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms
Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma
Within the tumour microenvironment, CD4+ T cells can promote or suppress antitumour
responses through the recognition of antigens presented by human leukocyte antigen (HLA) …
responses through the recognition of antigens presented by human leukocyte antigen (HLA) …
Identification of bacteria-derived HLA-bound peptides in melanoma
S Kalaora, A Nagler, D Nejman, M Alon, C Barbolin… - Nature, 2021 - nature.com
A variety of species of bacteria are known to colonize human tumours,,,,,,,,,–, proliferate
within them and modulate immune function, which ultimately affects the survival of patients …
within them and modulate immune function, which ultimately affects the survival of patients …
[HTML][HTML] Acquired resistance to immune checkpoint inhibitors
AJ Schoenfeld, MD Hellmann - Cancer cell, 2020 - cell.com
Immune checkpoint inhibitors (ICIs) have rapidly altered the treatment landscape for multiple
tumor types, providing unprecedented survival in some patients. Despite the characteristic …
tumor types, providing unprecedented survival in some patients. Despite the characteristic …
[HTML][HTML] T-cell exhaustion signatures characterize the immune landscape and predict HCC prognosis via integrating single-cell RNA-seq and bulk RNA-sequencing
H Chi, S Zhao, J Yang, X Gao, G Peng… - Frontiers in …, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC), the third most prevalent cause of cancer-
related death, is a frequent primary liver cancer with a high rate of morbidity and mortality. T …
related death, is a frequent primary liver cancer with a high rate of morbidity and mortality. T …
Tumour-intrinsic resistance to immune checkpoint blockade
Abstract 'Immune checkpoint blockade'for cancer describes the use of therapeutic antibodies
that disrupt negative immune regulatory checkpoints and unleash pre-existing antitumour …
that disrupt negative immune regulatory checkpoints and unleash pre-existing antitumour …
[HTML][HTML] The tumor microenvironment in the response to immune checkpoint blockade therapies
F Petitprez, M Meylan, A de Reyniès… - Frontiers in …, 2020 - frontiersin.org
Tumor cells constantly interact with their microenvironment, which comprises a variety of
immune cells together with endothelial cells and fibroblasts. The composition of the tumor …
immune cells together with endothelial cells and fibroblasts. The composition of the tumor …