[HTML][HTML] A perspective on the discovery of enzyme activators

A Turberville, H Semple, G Davies, D Ivanov… - SLAS Discovery, 2022 - Elsevier
Enzyme activation remains a largely under-represented and poorly exploited area of drug
discovery despite some key literature examples of the successful application of enzyme …

[HTML][HTML] High-throughput detection of metal contamination in HTS outputs

C Molyneux, I Sinclair, HL Lightfoot, J Walsh… - SLAS Discovery, 2022 - Elsevier
Large compound libraries utilised for HTS often include metal contaminated compounds
which can interfere with assay signal or target biology, and therefore appear as hits. Pursuit …

[HTML][HTML] AI4DR: Development and implementation of an annotation system for high-throughput dose-response experiments

M Bianciotto, L Colliandre, K Mi, I Schreiber… - Artificial Intelligence in …, 2023 - Elsevier
One of the common strategies to identify novel chemical matter in drug discovery consists in
performing a High Throughput Screening (HTS). However, the large amount of data …

The Relationship Between Customers' Satisfaction and Trust in the Global Supply Chain and Profitability

A Gilham - 2023 - search.proquest.com
The inability to meet customer demands and expectations impacts an organization's
profitability. Understanding and meeting customer needs are critical for the financial success …