Targeting IL-6 trans-signalling: past, present and future prospects

S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

IL-6/JAK/STAT3 signaling in breast cancer metastasis: biology and treatment

SG Manore, DL Doheny, GL Wong, HW Lo - Frontiers in oncology, 2022 - frontiersin.org
Breast cancer is the most commonly diagnosed cancer in women. Metastasis is the primary
cause of mortality for breast cancer patients. Multiple mechanisms underlie breast cancer …

Cytokines in inflammatory disease

S Kany, JT Vollrath, B Relja - International journal of molecular sciences, 2019 - mdpi.com
This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines.
Numerous studies have implicated that inflammatory cytokines exert important effects with …

Translating IL-6 biology into effective treatments

EH Choy, F De Benedetti, T Takeuchi… - Nature Reviews …, 2020 - nature.com
Abstract In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is
important for antibody production by B cells. Since its discovery more than 40 years ago, the …

Pro-inflammatory cytokines: The link between obesity and osteoarthritis

T Wang, C He - Cytokine & growth factor reviews, 2018 - Elsevier
Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

Targeting interleukin-6 signaling in clinic

S Kang, T Tanaka, M Narazaki, T Kishimoto - Immunity, 2019 - cell.com
Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …

IL-6 revisited: from rheumatoid arthritis to CAR T cell therapy and COVID-19

T Kishimoto, S Kang - Annual review of Immunology, 2022 - annualreviews.org
The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …

Interleukin-6: obstacles to targeting a complex cytokine in critical illness

OJ McElvaney, GF Curley, S Rose-John… - The Lancet …, 2021 - thelancet.com
Circulating concentrations of the pleiotropic cytokine interleukin-6 (IL-6) are known to be
increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory …

Pleiotropy and specificity: insights from the interleukin 6 family of cytokines

M Murakami, D Kamimura, T Hirano - Immunity, 2019 - cell.com
Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

Interleukin-6 family cytokines

S Rose-John - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary
neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM) …