TEA domain transcription factor 4 (TEAD4) is an important member of the TEAD family. As a
downstream effector of the Hippo pathway, TEAD4 has essential roles in cell proliferation …

The Hippo pathway is the major regulator of organ growth and proliferation. Described
initially in Drosophila, it is now recognized as one of the most conserved molecular …

Arginine plays diverse roles in cellular physiology. As a semi-essential amino acid, arginine
deprivation has been used to target cancers with arginine synthesis deficiency. Arginine …

Treating BRAF inhibitor-resistant melanoma is an important therapeutic goal. Thus, it is
important to identify and target mechanisms of resistance to improve therapy. The YAP1 and …

Objective Whether TEAD4 itself plays a vital role in the tumorigenesis and development of
lung adenocarcinoma remains unclear. In our study, we aim to investigate the expression …

Abstract Hippo Tumor Suppressor Pathway is the main pathway for cell growth that
regulates tissue enlargement and organ size by limiting cell growth. This pathway is …

Abstract The Salvador–Warts–Hippo pathway controls cell fate and tissue growth. The main
function of the Hippo pathway is to prevent YAP and TAZ translocation to the nucleus where …

TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein
of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in …

Abstract Background Deregulated Hippo signaling has been uncovered to be intricately
involved in tumorigenesis. Transcriptional factor TEADs serve as key mediators of Hippo …

Consistent with their diverse pharmacology, peptides derived from venomous animals have
been developed as drugs to treat disorders as diverse as hypertension, diabetes and …