Review on Alzheimer's disease: inhibition of amyloid beta and tau tangle formation
It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …
Dementia is a group of symptoms that affect neurons and cause some mental disorders …
Synthesis of heterocycles via electrophilic cyclization of alkynes containing heteroatom
The interest in synthesizing heterocycles has always been enormous. The literature contains
a variety of synthetic approaches to the heterocycle ring structures, much of which has been …
a variety of synthetic approaches to the heterocycle ring structures, much of which has been …
Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …
an overwhelming health, social, economic, and political problem to nations. Unless a new …
Bioactive benzofuran derivatives: An insight on lead developments, radioligands and advances of the last decade
A Radadiya, A Shah - European journal of medicinal chemistry, 2015 - Elsevier
Benzofuran core is a highly versatile, presents in many important natural products and
natural drugs. Many benzofuran containing synthetic drugs and clinical candidates have …
natural drugs. Many benzofuran containing synthetic drugs and clinical candidates have …
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998–2018)
Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …
neurodegenerative disorder of the brain which involves multiple associated etiological …
Triazole derivatives as inhibitors of Alzheimer's disease: current developments and structure-activity relationships
M Xu, Y Peng, L Zhu, S Wang, J Ji… - European journal of …, 2019 - Elsevier
Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of
people worldwide and the subsequent epidemiological statistics highlights the implication of …
people worldwide and the subsequent epidemiological statistics highlights the implication of …
The magic of crystal structure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity
U Kosak, B Brus, D Knez, S Zakelj… - Journal of medicinal …, 2018 - ACS Publications
The enzymatic activity of butyrylcholinesterase (BChE) in the brain increases with the
progression of Alzheimer's disease, thus classifying BChE as a promising drug target in …
progression of Alzheimer's disease, thus classifying BChE as a promising drug target in …
Multi-target-directed ligands in Alzheimer's disease treatment
M Bajda, N Guzior, M Ignasik… - Current medicinal …, 2011 - ingentaconnect.com
Among the various drug discovery methods, a very promising modern approach consists in
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …
An electrochemical sensor for detection of neurotransmitter-acetylcholine using metal nanoparticles, 2D material and conducting polymer modified electrode
An essential biological sensor for acetylcholine (ACh) detection is constructed by
immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the …
immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the …
Benzofuran and indole: promising scaffolds for drug development in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
accepted treatment to cure or halt its progression. The Food and Drug Administration has …