Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer

F Sheikhnia, V Rashidi, H Maghsoudi… - Cancer cell …, 2023 - Springer
Colorectal neoplasms are one of the deadliest diseases among all cancers worldwide.
Thymoquinone (TQ) is a natural compound of Nigella sativa that has been used in traditional …

[HTML][HTML] Targeting FMS-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia: Novel molecular approaches and therapeutic challenges

J Rataj, L Gorecki, D Muthna, A Sorf, V Krystof… - Biomedicine & …, 2025 - Elsevier
Acute myeloid leukemia (AML), a heterogeneous hematologic malignancy, has generally a
poor prognosis despite the recent advancements in diagnostics and treatment. Genetic …

[HTML][HTML] Involvement of Nrf2, JAK and COX pathways in acetaminophen-induced nephropathy: Role of some antioxidants

QH Alqahtani, LM Fadda, AM Alhusaini… - Saudi Pharmaceutical …, 2023 - Elsevier
Objectives Acetaminophen (APAP)-induced nephrotoxicity is detrimental consequence for
which there has not been a standardized therapeutic regimen. Although, N-acetylcysteine …

Lung cancer exosomal Gal3BP promotes osteoclastogenesis with potential connotation in osteolytic metastasis

P Ghanta, E Hessel, A Arias-Alvarado, M Aghayev… - Scientific Reports, 2024 - nature.com
New insights into cellular interactions and key biomolecules involved in lung cancer (LC)
bone metastasis could offer remarkable therapeutic benefits. Using a panel of four LC cells …

Indirubin, an Active Component of Indigo Naturalis, Exhibits Inhibitory Effects on Leukemia Cells via Targeting HSP90AA1 and PI3K/Akt Pathway

Y Yao, X Li, X Yang, H Mou… - Anti-Cancer Agents in …, 2024 - ingentaconnect.com
Background: This research intended to predict the active ingredients and key target genes of
Indigo Naturalis in treating human chronic myeloid leukemia (CML) using network …

Immune-Stimulating Potential of Lacticaseibacillus rhamnosus LM1019 in RAW 264.7 Cells and Immunosuppressed Mice Induced by Cyclophosphamide

Y You, SH Kim, CH Kim, IH Kim, YS Shin, TR Kim… - Microorganisms, 2023 - mdpi.com
Probiotics, including Lacticaseibacillus rhamnosus (L. rhamnosus), have gained recognition
for their potential health benefits, such as enhancing immune function, maintaining gut …

Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling Pathway

FA Al-Rawashde, OM Al-Sanabra, M Alqaraleh… - Pharmaceuticals, 2023 - mdpi.com
The epigenetic silencing of tumor suppressor genes (TSGs) is critical in the development of
chronic myeloid leukemia (CML). SHP-1 functions as a TSG and negatively regulates …

[HTML][HTML] SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

HM Otifi - Oncology Research, 2024 - pmc.ncbi.nlm.nih.gov
Background Gastric cancer (GC) remains a global health burden and is often characterized
by heterogeneous molecular profiles and resistance to conventional therapies. The …

Recent Advances in Signaling Pathways and Kinase Inhibitors for Leukemia Chemotherapy

Y Liu, Z Yang, Q Zhang, P Hai, Y Zheng… - Current Medicinal …, 2024 - ingentaconnect.com
Leukemia is a malignant clonal disease of hematopoietic stem cells, which accounts for
about 3% of the total incidence of tumors and is particularly prevalent among children and …

M3NetFlow: a novel multi-scale multi-hop multi-omics graph AI model for omics data integration and interpretation

H Zhang, SP Goedegebuure, L Ding, W Hawkins… - bioRxiv, 2023 - biorxiv.org
The integration and interpretation of multi-omics data play a crucial role in systems biology
for prioritizing vital molecular targets and deciphering core signaling pathways of complex …