Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs

W Jing, C Liu, C Su, L Liu, P Chen, X Li… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial
inflammation, pannus formation, and bone and cartilage damage. It has a high disability …

Fractionated whole body γ-irradiation aggravates arthritic severity via boosting NLRP3 and RANKL expression in adjuvant-induced arthritis model: the mitigative …

NM Thabet, MK Abdel-Rafei, MM Amin - Inflammopharmacology, 2023 - Springer
Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease associated with
oxidative stress that causes excruciating pain, discomfort, and joint destruction. Ebselen …

[HTML][HTML] (Chemical) Roles of HOCl in Rheumatic Diseases

J Leopold, J Schiller - Antioxidants, 2024 - pmc.ncbi.nlm.nih.gov
Chronic rheumatic diseases such as rheumatoid arthritis (RA) are characterized by a
dysregulated immune response and persistent inflammation. The large number of …

Vitamin E analog trolox attenuates MPTP-induced Parkinson's disease in mice, mitigating oxidative stress, neuroinflammation, and motor impairment

A Atiq, HJ Lee, A Khan, MH Kang, IU Rehman… - International Journal of …, 2023 - mdpi.com
Trolox is a potent antioxidant and a water-soluble analog of vitamin E. It has been used in
scientific studies to examine oxidative stress and its impact on biological systems. Trolox has …

Schisandrin B ameliorates adjuvant-induced arthritis in rats via modulation of inflammatory mediators, oxidative stress, and HIF-1α/VEGF pathway

X Chen, C Liu, J Deng, T Xia, X Zhang… - Journal of Pharmacy …, 2024 - academic.oup.com
Abstract Objectives Schisandrin B (Sch B) has been shown to possess anti-inflammatory
and antioxidant properties, however, its antirheumatoid arthritis properties and potential …

Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis

C Zhao, Y Yu, G Yin, C Xu, J Wang, L Wang… - …, 2024 - Springer
Objective Ferroptosis has been reported to play a role in rheumatoid arthritis (RA).
Sulfasalazine, a common clinical treatment for ankylosing spondylitis, also exerts …

Appraisal of anti-inflammatory and immunomodulatory potential of ramipril against Freund's adjuvant-provoked arthritic rat model

S Qasim, YH Khan, AM Uttra, NH Alotaibi… - …, 2023 - Springer
Because of evident role of renin–angiotensin system in the etiology of rheumatoid arthritis,
the current study's objective was to assess the anti-arthritic efficacy of ramipril through CFA …

A Novel Hydroxyapatite/Vitamin B12 Nanoformula for Treatment of Bone Damage: Preparation, Characterization, and Anti-Arthritic, Anti-Inflammatory, and Antioxidant …

A Belal, R Mahmoud, EE Mohamed, A Farghali… - Pharmaceuticals, 2023 - mdpi.com
The usage of nanomaterials for rheumatoid arthritis (RA) treatment can improve
bioavailability and enable selective targeting. The current study prepares and evaluates the …

Enalapril attenuated CFA provoked arthritic manifestation by modulating proinflammatory and anti-inflammatory cytokine network

YH Khan, S Qasim, AM Uttra, NH Alotaibi, AS Alanazi… - Life Sciences, 2023 - Elsevier
Enalapril with documented anti-inflammatory potential was evaluated in current investigation
to explore its anti-arthritic efficacy. For anti-arthritic evaluation of enalapril, CFA-instigated …

Curcumin Co-Encapsulation Potentiates Anti-Arthritic Efficacy of Meloxicam Biodegradable Nanoparticles in Adjuvant-Induced Arthritis Animal Model

B Aslam, A Hussain, MN Faisal, ZD Sindhu, RU Khan… - Biomedicines, 2023 - mdpi.com
This study aimed to evaluate the anti-arthritic activity of curcumin and meloxicam co-loaded
PLGA nanoparticles in adjuvant-induced arthritic rats. PLGA nanoparticles encapsulating …