Label-free live cell recognition and tracking for biological discoveries and translational applications

B Chen, Z Yin, BWL Ng, DM Wang, RS Tuan, R Bise… - npj Imaging, 2024 - nature.com
Label-free, live cell recognition (ie instance segmentation) and tracking using computer
vision-aided recognition can be a powerful tool that rapidly generates multi-modal readouts …

Beyond a Transmission Cable—New Technologies to Reveal the Richness in Axonal Electrophysiology

JC Mateus, MM Sousa, J Burrone… - Journal of …, 2024 - Soc Neuroscience
The axon is a neuronal structure capable of processing, encoding, and transmitting
information. This assessment contrasts with a limiting, but deeply rooted, perspective where …

Robotic rotational positioning of end-effectors for micromanipulation

S Zhuang, C Dai, G Shan, C Ru… - IEEE Transactions on …, 2022 - ieeexplore.ieee.org
Precise rotational positioning of end-effectors under microscopy is crucial for robotic
micromanipulation. However, the end-effector is presently limited to a fixed orientation …

Deep learning-enabled mobile application for efficient and robust herb image recognition

X Sun, H Qian, Y Xiong, Y Zhu, Z Huang, F Yang - Scientific Reports, 2022 - nature.com
With the increasing popularity of herbal medicine, high standards of the high quality control
of herbs becomes a necessity, with the herb recognition as one of the great challenges. Due …

Neuron Contact Detection Based on Pipette Precise Positioning for Robotic Brain-Slice Patch Clamps

K Li, H Gong, J Qiu, R Li, Q Zhao, X Zhao, M Sun - Sensors, 2023 - mdpi.com
A patch clamp is the “gold standard” method for studying ion-channel biophysics and
pharmacology. Due to the complexity of the operation and the heavy reliance on …

Robotic patch clamp based on noninvasive 3-D cell morphology measurement for higher success rate

Q Zhao, J Qiu, Y Han, Y Jia, Y Du… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
The formation of the gigaseal, a giga Omega-scale seal between the micropipette electrode
and cell surface, is the keystone to measure the extremely weak electric signals of cell ion …

[HTML][HTML] Current approaches to characterize micro-and macroscale circuit mechanisms of Parkinson's disease in rodent models

Y Peng, N Schöneberg, MS Esposito, JRP Geiger… - Experimental …, 2022 - Elsevier
Accelerating technological progress in experimental neuroscience is increasing the scale as
well as specificity of both observational and perturbational approaches to study circuit …

Multimodal spatiotemporal drug assessment platform based on a microelectrode neural network chip in Alzheimer's disease

F Gao, W Xu, Y Xiao, W Jiang, M Chen, Z Liu… - Chemical Engineering …, 2024 - Elsevier
The pathogenesis of Alzheimer's disease (AD) remains elusive. The development of new
drugs is protracted, costly, and fraught with failure, largely due to the lack of convenient …

High-throughput genetic manipulation of multicellular organisms using a machine-vision guided embryonic microinjection robot

AD Alegria, AS Joshi, JB Mendana, K Khosla… - Genetics, 2024 - academic.oup.com
Microinjection is a technique used for transgenesis, mutagenesis, cell labeling,
cryopreservation, and in vitro fertilization in multiple single and multicellular organisms …

Harnessing the potential of human induced pluripotent stem cells, functional assays and machine learning for neurodevelopmental disorders

Z Yang, NA Teaney, ED Buttermore, M Sahin… - Frontiers in …, 2025 - frontiersin.org
Neurodevelopmental disorders (NDDs) affect 4.7% of the global population and are
associated with delays in brain development and a spectrum of impairments that can lead to …