Human immunodeficiency virus drug resistance: 2018 recommendations of the International Antiviral Society–USA Panel
HF Günthard, V Calvez, R Paredes… - Clinical Infectious …, 2019 - academic.oup.com
Background Contemporary antiretroviral therapies (ART) and management strategies have
diminished both human immunodeficiency virus (HIV) treatment failure and the acquired …
diminished both human immunodeficiency virus (HIV) treatment failure and the acquired …
We should not stop considering HIV drug resistance testing at failure of first-line antiretroviral therapy
R Kantor, RK Gupta - The Lancet HIV, 2023 - thelancet.com
HIV drug resistance is a major global hurdle to successful and sustained antiretroviral
therapy. Global guidelines recommend testing for antiretroviral drug resistance and results …
therapy. Global guidelines recommend testing for antiretroviral drug resistance and results …
Addressing an HIV cure in LMIC
HIV-1 persists in infected individuals despite years of antiretroviral therapy (ART), due to the
formation of a stable and long-lived latent viral reservoir. Early ART can reduce the latent …
formation of a stable and long-lived latent viral reservoir. Early ART can reduce the latent …
Infecting HIV-1 subtype predicts disease progression in women of sub-Saharan Africa
CM Venner, I Nankya, F Kyeyune, K Demers, C Kwok… - …, 2016 - thelancet.com
Introduction Long-term natural history cohorts of HIV-1 in the absence of treatment provide
the best measure of virulence by different viral subtypes. Methods Newly HIV infected …
the best measure of virulence by different viral subtypes. Methods Newly HIV infected …
Nucleoside reverse-transcriptase inhibitor cross-resistance and outcomes from second-line antiretroviral therapy in the public health approach: an observational …
NI Paton, C Kityo, J Thompson, I Nankya, L Bagenda… - The lancet HIV, 2017 - thelancet.com
Background Cross-resistance after first-line antiretroviral therapy (ART) failure is expected to
impair activity of nucleoside reverse-transcriptase inhibitors (NRTIs) in second-line therapy …
impair activity of nucleoside reverse-transcriptase inhibitors (NRTIs) in second-line therapy …
Successes and challenges in optimizing the viral load cascade to improve antiretroviral therapy adherence and rationalize second‐line switches in Swaziland
D Etoori, I Ciglenecki, M Ndlangamandla… - Journal of the …, 2018 - Wiley Online Library
Introduction As antiretroviral therapy (ART) is scaled up, more patients become eligible for
routine viral load (VL) monitoring, the most important tool for monitoring ART efficacy. For …
routine viral load (VL) monitoring, the most important tool for monitoring ART efficacy. For …
Pretreatment HIV drug resistance and HIV-1 subtype C are independently associated with virologic failure: results from the multinational PEARLS (ACTG A5175) …
R Kantor, L Smeaton, S Vardhanabhuti… - Clinical infectious …, 2015 - academic.oup.com
Background. Evaluation of pretreatment HIV genotyping is needed globally to guide
treatment programs. We examined the association of pretreatment (baseline) drug …
treatment programs. We examined the association of pretreatment (baseline) drug …
A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells
We compared different techniques for measuring gut HIV reservoirs and assessed for HIV in
non-CD4+ T cells. HIV DNA levels were similar when measured from rectal biopsies and …
non-CD4+ T cells. HIV DNA levels were similar when measured from rectal biopsies and …
Low-frequency drug resistance in HIV-infected Ugandans on antiretroviral treatment is associated with regimen failure
F Kyeyune, RM Gibson, I Nankya… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Most patients failing antiretroviral treatment in Uganda continue to fail their treatment
regimen even if a dominant drug-resistant HIV-1 genotype is not detected. In a recent …
regimen even if a dominant drug-resistant HIV-1 genotype is not detected. In a recent …
HIV-1 second-line failure and drug resistance at high-level and low-level viremia in Western Kenya
R Kantor, A DeLong, L Schreier, M Reitsma, E Kemboi… - Aids, 2018 - journals.lww.com
Objective: Characterize failure and resistance above and below guidelines-recommended
1000 copies/ml virologic threshold, upon second-line failure. Design: Cross-sectional study …
1000 copies/ml virologic threshold, upon second-line failure. Design: Cross-sectional study …