Abstract Receptor-interacting protein 1 (RIP1) kinase has emerged as a key upstream
regulator that controls inflammatory signalling as well as the activation of multiple cell death …

Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent
evidence has shown that the control of multiple immune functions, including chronic …

Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …

Inhibitor of apoptosis (IAP) proteins are antiapoptotic regulators that block cell death in
response to diverse stimuli. They are expressed at elevated levels in human malignancies …

XIAP prevents apoptosis by binding to and inhibiting caspases, and this inhibition can be
relieved by IAP antagonists, such as Smac/DIABLO. IAP antagonist compounds (IACs) have …

Misregulated innate immune signaling and cell death form the basis of much human disease
pathogenesis. Inhibitor of apoptosis (IAP) protein family members are frequently …

Defects in apoptosis regulation are one main cause of cancer development and may result
from overexpression of anti-apoptotic proteins such as inhibitor of apoptosis proteins (IAPs) …

Recent genetic evidence has established a pathogenetic role for NF-κB signaling in cancer.
NF-κB signaling is engaged transiently when normal B lymphocytes respond to antigens, but …

The cellular inhibitor of apoptosis 1 and 2 (cIAP1 and cIAP2) proteins have been implicated
in the activation of NF-κB by TNFα; however, genetic deletion of either cIAP1 or 2 did not …

DNA damage, chromosomal abnormalities, oncogene activation, viral infection, substrate
detachment and hypoxia can all trigger apoptosis in normal cells. However, cancer cells …