This guideline presents recommendations for the management of patients with hereditary
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …

Colorectal cancer (CRC) is the fourth most common cancer amongst men and women.
Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including …

Disclaimer: The practice guidelines of the American College of Medical Genetics and
Genomics (ACMG) and the National Society of Genetic Counselors (NSGC) are developed …

Around 10% to 16% 1–4 of all individuals with colorectal cancer have a pathogenic variant
in a cancer susceptibility gene (Table 1). While not all of these genes have been associated …

Accurate estimation of recent shared ancestry is important for genetics, evolution, medicine,
conservation biology, and forensics. Established methods estimate kinship accurately for …

Familial adenomatous polyposis (FAP) syndrome is a complex entity, which includes FAP,
attenuated FAP, and MUTYH-associated polyposis. These patients are at significant risk for …

Abstract Background The Japanese Society of Gastroenterology (JSGE) published ''Daicho
Polyp Shinryo Guideline 2014′'in Japanese and a part of this guideline was published in …

© 2022, Smith, Fraser, Reed, Barlow, Hanson, West, Knight, Forsythe, Mineau This open-
access work is licensed under a Creative Commons Attribution 4.0 International License …

Hereditary causes due to mutations and defects in certain genes account for roughly 5% to
10% of all colorectal cancers. These inherited syndromes have been associated with a 60 …

BACKGROUND & AIMS: Gastrointestinal polyposis is a common clinical problem, yet there
is no consensus on how to best manage patients with moderate-load polyposis. Identifying …