Perimenopause is a midlife transition state experienced by women that occurs in the context
of a fully functioning neurological system and results in reproductive senescence. Although …

Next-generation sequencing technologies have revolutionarily advanced sequence-based
research with the advantages of high-throughput, high-sensitivity, and high-speed. RNA-seq …

In this paper, we characterize major depression (MD) as a complex dynamic system in which
symptoms (eg, insomnia and fatigue) are directly connected to one another in a network …

About 17% of humanity goes through an episode of major depression at some point in their
lifetime. Despite the enormous societal costs of this incapacitating disorder, it is largely …

Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage
requires broad changes of their gene expression profile. But how progenitor cells overcome …

Chronic diseases (ie, noncommunicable diseases), mainly cardiovascular disease, cancer,
respiratory diseases and type-2-diabetes, are now the leading cause of death, disability and …

Many systems on our planet shift abruptly and irreversibly from the desired state to an
undesired state when forced across a “tipping point”. Some examples are mass extinctions …

Developing predictive biomarkers that can detect the tipping point before metastasis of
hepatocellular carcinoma (HCC), is critical to prevent further irreversible deterioration. To …

We develop an auto-reservoir computing framework, Auto-Reservoir Neural Network
(ARNN), to efficiently and accurately make multi-step-ahead predictions based on a short …

Recently, there has been a coordinated effort from academic institutions and the
pharmaceutical industry to identify biomarkers that can predict responses to immune …