Pulmonary arterial hypertension: pathogenesis and clinical management

T Thenappan, ML Ormiston, JJ Ryan, SL Archer - Bmj, 2018 - bmj.com
Pulmonary hypertension is defined as a resting mean pulmonary artery pressure of 25 mm
Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of …

The use of nanotechnology in cardiovascular disease

M Chandarana, A Curtis, C Hoskins - Applied Nanoscience, 2018 - Springer
Cardiovascular diseases claim a number of lives globally; many of which are preventable.
With the increase in diets that consist of high saturated fat, salt, and sugar, people often …

Decorin: a growth factor antagonist for tumor growth inhibition

TAH Järvinen, S Prince - BioMed research international, 2015 - Wiley Online Library
Decorin (DCN) is the best characterized member of the extracellular small leucine‐rich
proteoglycan family present in connective tissues, typically in association with or …

Protein and peptide delivery to lungs by using advanced targeted drug delivery

DK Chellappan, P Prasher, V Saravanan… - Chemico-biological …, 2022 - Elsevier
The challenges and difficulties associated with conventional drug delivery systems have led
to the emergence of novel, advanced targeted drug delivery systems. Therapeutic drug …

Effects of fasudil on pulmonary hypertension in clinical practice

Y Zhang, S Wu - Pulmonary pharmacology & therapeutics, 2017 - Elsevier
Pulmonary hypertension (PH) is a pathophysiologic disorder that may involve multiple
clinical conditions and can complicate the majority of cardiovascular and respiratory …

Nanomedicine-mediated therapeutic approaches for pulmonary arterial hypertension

E Mirhadi, P Kesharwani, TP Johnston… - Drug Discovery Today, 2023 - Elsevier
Highlights•Nanomedicine has emerged as a field with great opportunities to improve
treatment strategies.•Pulmonary arterial hypertension (PAH) is a serious and incurable …

Newer approaches and novel drugs for inhalational therapy for pulmonary arterial hypertension

A Keshavarz, H Kadry, A Alobaida… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction: Pulmonary arterial hypertension (PAH) is a progressive disease characterized
by remodeling of small pulmonary arteries leading to increased pulmonary arterial pressure …

Decorin in the tumor microenvironment

K Baghy, A Reszegi, P Tátrai, I Kovalszky - … Matrix Components–Part B, 2020 - Springer
The tumor microenvironment plays a determining role in cancer development through a
plethora of interactions between the extracellular matrix and tumor cells. Decorin is a …

Review peptide‐targeted liposomes for selective drug delivery: Advantages and problematic issues

A Accardo, G Morelli - Peptide Science, 2015 - Wiley Online Library
We describe the use of bioactive peptides to drive liposomal drugs on target receptors
overexpressed in cancer cells. A detailed description for several targeting liposomes …

Generation of a multi‐functional, target organ‐specific, anti‐fibrotic molecule by molecular engineering of the extracellular matrix protein, decorin

TAH Järvinen, E Ruoslahti - British Journal of Pharmacology, 2019 - Wiley Online Library
Extracellular matrix (ECM) molecules play important roles in regulating processes such as
cell proliferation, migration, differentiation and survival. Decorin is a proteoglycan that binds …