Modern thrombophilia testing fails to identify any underlying prothrombotic tendency in a
significant number of patients presenting with objectively confirmed venous …

Venous thrombosis occurs in about 1 per 1,000 individuals per year. 1, 2 It usually affects
the deep veins of the leg, but may occur in other sites, such as the upper extremities …

Background A high plasma level of factor VIII is a risk factor for venous thromboembolism.
We evaluated the risk of a recurrence of thrombosis after an initial episode of spontaneous …

Thrombophilia can be defined as a predisposition to form clots inappropriately. Thrombotic
events during infancy and childhood are increasingly recognized as a significant source of …

Established risk factors, including deficiencies of protein C, protein S or antithrombin and the
factor V Leiden and prothrombin mutation, are present in about one third of unselected …

The development of thrombotic disorders in humans is one of the most common causes of
morbidity and mortality in the Western world. Thrombotic disease can be classified in broad …

Factor VIII: C levels show a familial clustering, which remains after adjustment for the
influence of vWF and blood group. 46 Analysis of familial aggregation of factor VIII levels …

During the past decade, the role of inflammation in the pathophysiology of arterial
thrombosis has been elucidated. However, comparatively little is known about the …

Venous thrombosis, whose main clinical presentations include deep vein thrombosis and
pulmonary embolism, represents a major health problem worldwide. Numerous conditions …

Ensuring quality has become a daily requirement in laboratories. In haemostasis, even more
than in other disciplines of biology, quality is determined by a pre-analytical step that …