Optogenetics is widely used to interrogate the neural circuits underlying disease and has
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …

Can we construct a model of brain function that enables an understanding of whole-brain
circuit mechanisms underlying neurological disease and use it to predict the outcome of …

Cell therapies as potential treatments for Parkinson's disease first gained traction in the
1980s, owing to the clinical success of trials that used transplants of foetal midbrain …

Neuropsychiatric disorders place an enormous medical burden on patients across all social
and economic ranks. The current understanding of the molecular and cellular causes of …

Central thalamus plays a critical role in forebrain arousal and organized behavior. However,
network-level mechanisms that link its activity to brain state remain enigmatic. Here, we …

Recent developments of optogenetic tools and fluorescence-based calcium recording
techniques enable the manipulation and monitoring of neural circuits on a cellular level. Non …

The controlled differentiation of pluripotent stem cells (PSCs) into neurons and glia offers a
unique opportunity to study early stages of human central nervous system development …

Background and objective Optogenetics has opened new insights into biomedical research
with the ability to manipulate and control cellular activity using light in combination with …

Stem cell transplantation holds a promising future for central nervous system repair. Current
challenges, however, include spatially and temporally defined cell differentiation and …

In vivo optical imaging has emerged as a powerful tool with which to study cellular
responses to injury and disease in the mammalian CNS. Important new insights have …