One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that
include the methionine and folate cycles that are central to cellular function, providing 1C …

BACKGROUND Although laboratory procedures, along with culture media formulations,
have improved over the past two decades, the issue remains that human IVF is performed in …

BACKGROUND Most reproductive failures originate during the periconceptional period and
are influenced by the age and the lifestyle of parents-to-be. We advance the hypothesis that …

Epidemiological studies have indicated that susceptibility of human adults to hypertension
and cardiovascular disease may result from intrauterine growth restriction and low birth …

BACKGROUND The advances in the world of IVF during the last decades have been rapid
and impressive and culture media play a major role in this success. Until the 1980s fertility …

This review presents an overview of the technical bases of in vivo and in vitro embryo
production in sheep and goat. The current limitations of in vivo production, such as variability …

The large offspring syndrome (LOS) is observed in bovine and ovine offspring following
transfer of in vitro-produced (IVP) or cloned embryos and is characterized by a multitude of …

Recent advances in molecular technology and in vitro production of bovine embryos have
enabled studies of gene transcription in preimplantation embryos. On the basis of …

Contents In general, the majority of immature bovine oocytes fail to develop to the blastocyst
stage following maturation, fertilization and culture in vitro. The evidence suggests that while …

The preimplantation mammalian embryo from different species appears sensitive to the
environment in which it develops, either in vitro or in vivo, for example, in response to culture …