Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

[HTML][HTML] The human HSP70 family of chaperones: where do we stand?

J Radons - Cell Stress and Chaperones, 2016 - Elsevier
The 70-kDa heat shock protein (HSP70) family of molecular chaperones represents one of
the most ubiquitous classes of chaperones and is highly conserved in all organisms …

Plasma exosomes protect the myocardium from ischemia-reperfusion injury

JM Vicencio, DM Yellon, V Sivaraman, D Das… - Journal of the American …, 2015 - jacc.org
Background: Exosomes are nanometer-sized vesicles released from cells into the blood,
where they can transmit signals throughout the body. Shown to act on the heart, exosomes' …

Heat shock proteins as regulators of the immune response

AG Pockley - The lancet, 2003 - thelancet.com
Until recently, heat shock proteins (also known as heat stress proteins) have mostly been
regarded as intracellular molecules that mediate a range of essential housekeeping and …

[HTML][HTML] Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell …

A De Maio - Cell Stress and Chaperones, 2011 - Elsevier
Heat shock proteins (hsp) have been found to play a fundamental role in the recovery from
multiple stress conditions and to offer protection from subsequent insults. The function of hsp …

The anti-inflammatory mechanisms of Hsp70

TJ Borges, L Wieten, MJC van Herwijnen… - Frontiers in …, 2012 - frontiersin.org
Immune responses to heat shock proteins (Hsp) develop in virtually all inflammatory
diseases; however, the significance of such responses is only now becoming clear. In …

Trauma-induced damage-associated molecular patterns-mediated remote organ injury and immunosuppression in the acutely ill patient

M Vourc'h, A Roquilly, K Asehnoune - Frontiers in immunology, 2018 - frontiersin.org
Trauma is one of the leading causes of death and disability in the world. Multiple trauma or
isolated traumatic brain injury are both indicative of human tissue damage. In the early …

Heat shock protein 70 as a double agent acting inside and outside the cell: insights into autoimmunity

S Tukaj - International Journal of Molecular Sciences, 2020 - mdpi.com
Heat shock proteins (Hsp) are a diverse group of constitutive and/or stress-induced
molecules that are categorized into several classes on the basis of their molecular weight …

Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor α release by …

B Gao, MF Tsan - Journal of Biological Chemistry, 2003 - ASBMB
Using commercially available recombinant human heat shock protein 70 (rhHsp70), recent
studies have shown that rhHsp70 could induce the production of tumor necrosis factor α …

Extracellular cell stress (heat shock) proteins—immune responses and disease: an overview

AG Pockley, B Henderson - Philosophical transactions of …, 2018 - royalsocietypublishing.org
Extracellular cell stress proteins are highly conserved phylogenetically and have been
shown to act as powerful signalling agonists and receptors for selected ligands in several …