[HTML][HTML] Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis
Aging is a risk factor for the development of osteoarthritis (OA), a progressive joint disease
leading to cartilage damage, pain, and loss of function. In a mouse model of OA, senolytic …
leading to cartilage damage, pain, and loss of function. In a mouse model of OA, senolytic …
Matrix metalloproteinase inhibition with doxycycline affects the progression of posttraumatic osteoarthritis after anterior cruciate ligament rupture: evaluation in a new …
X Zhang, XH Deng, Z Song, B Croen… - … American journal of …, 2020 - journals.sagepub.com
Background: Doxycycline has broad-spectrum activity as a matrix metalloproteinase (MMP)
inhibitor and thus could reduce the progression of posttraumatic osteoarthritis (PTOA) after …
inhibitor and thus could reduce the progression of posttraumatic osteoarthritis (PTOA) after …
Pharmacokinetics and distribution of minocycline in mature horses after oral administration of multiple doses and comparison with minimum inhibitory concentrations
LV Schnabel, MG Papich, TJ Divers… - Equine veterinary …, 2012 - Wiley Online Library
Reasons for performing study: Minocycline holds great potential for use in horses not only
for its antimicrobial effects but also for its anti‐inflammatory and neuroprotective properties …
for its antimicrobial effects but also for its anti‐inflammatory and neuroprotective properties …
Borreliosis in sport horse practice
EL Swinebroad - Veterinary Clinics: Equine Practice, 2018 - vetequine.theclinics.com
The foundational work of sport horse practice is evaluating soundness and performance,
defining and correcting unsoundness noted on physical examination, and returning the …
defining and correcting unsoundness noted on physical examination, and returning the …
Doxycycline concentration over time after storage in a compounded veterinary preparation
MG Papich, GS Davidson… - Journal of the American …, 2013 - Am Vet Med Assoc
Objective—To determine the concentration of doxycycline compounded from doxycycline
hyclate tablets into liquid formulations for oral administration in veterinary species and …
hyclate tablets into liquid formulations for oral administration in veterinary species and …
Factors associated with survival and return to function following synovial infections in horses
Synovial infections (SI) are common in horses of all ages and can be associated with high
rates of morbidity and mortality. Identifying factors influencing survival and return to function …
rates of morbidity and mortality. Identifying factors influencing survival and return to function …
[HTML][HTML] Effects of doxycycline on mesenchymal stem cell chondrogenesis and cartilage repair
OBJECTIVE: Strategies to improve cartilage repair tissue quality after bone marrow cell-
based procedures may reduce later development of osteoarthritis. Doxycycline is …
based procedures may reduce later development of osteoarthritis. Doxycycline is …
Chondrocyte proliferation, viability and differentiation is declined following administration of methylphenidate utilized for the treatment of attention-deficit/hyperactivity …
F Gumustas, I Yilmaz, DY Sirin… - Human & …, 2017 - journals.sagepub.com
Purpose: Methylphenidate (MPH) derivative drugs are used because of psychostimulants
effects on attention-deficit hyperactivity disorder in children and adults. As far as we know …
effects on attention-deficit hyperactivity disorder in children and adults. As far as we know …
Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL‐1α and MMP‐13‐induced catabolic gene responses
LA Fortier, T Motta, RA Greenwald… - Journal of …, 2010 - Wiley Online Library
The objective of this study was to determine the primary articular tissue target of doxycycline
and minocycline. Synoviocytes—cartilage cocultures (n= 4) were treated with MMP‐13 (25 …
and minocycline. Synoviocytes—cartilage cocultures (n= 4) were treated with MMP‐13 (25 …
Pharmacokinetics and distribution of voriconazole in body fluids of dogs after repeated oral dosing
JD Lemetayer, PM Dowling, SM Taylor… - Journal of Veterinary …, 2015 - Wiley Online Library
The goal of this project was to determine the pharmacokinetics of voriconazole and its
concentration in cerebrospinal fluid (CSF), aqueous humor, and synovial fluid in five healthy …
concentration in cerebrospinal fluid (CSF), aqueous humor, and synovial fluid in five healthy …