The enzyme carboxyl ester lipase (CEL), also known as bile salt-dependent or-stimulated
lipase (BSDL, BSSL), hydrolyzes dietary fat, cholesteryl esters and fat-soluble vitamins in the …

Carboxyl ester lipase is a digestive pancreatic enzyme encoded by the CEL gene. Mutations
in CEL cause maturity-onset diabetes of the young as well as pancreatic exocrine …

Non-alcoholic fatty liver disease (NAFLD) derives from the accumulation of hepatic lipids,
which leads to liver steatosis and then triggers non-alcoholic steatohepatitis, sometimes …

MODY8 (maturity-onset diabetes of the young, type 8) is a dominantly inherited monogenic
form of diabetes associated with mutations in the carboxyl ester lipase (CEL) gene …

Background Diagnosis of monogenic as well as atypical forms of diabetes mellitus has
important clinical implications for their specific diagnosis, prognosis, and targeted treatment …

Context Maturity onset diabetes of the young, type 8 (MODY8) is associated with mutations
in the CEL gene, which encodes the digestive enzyme carboxyl ester lipase. Several …

A recently discovered class of endogenous mammalian lipids, branched fatty acid esters of
hydroxy fatty acids (FAHFAs), possesses anti-diabetic and anti-inflammatory activities. Here …

Patients with chronic pancreatitis (CP) frequently have genetic risk factors for disease. Many
of the identified genes have been connected to trypsinogen activation or trypsin inactivation …

Background & aims The CEL gene encodes the digestive enzyme carboxyl ester lipase.
CEL-HYB1, a hybrid allele of CEL and its adjacent pseudogene CELP, is a genetic variant …

Variable number of tandem repeat (VNTR) sequences in the genome can have functional
consequences that contribute to human disease. This is the case for the CEL gene, which is …