The role of lipid components in lipid nanoparticles for vaccines and gene therapy

CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …

Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Stealth and pseudo-stealth nanocarriers

P Wen, W Ke, A Dirisala, K Toh, M Tanaka… - Advanced drug delivery …, 2023 - Elsevier
The stealth effect plays a central role on capacitating nanomaterials for drug delivery
applications through improving the pharmacokinetics such as blood circulation …

Tannic acid: A crosslinker leading to versatile functional polymeric networks: A review

C Chen, H Yang, X Yang, Q Ma - RSC advances, 2022 - pubs.rsc.org
With the thriving of mussel-inspired polyphenol chemistry as well as the demand for low-cost
analogues to polydopamine in adhesive design, tannic acid has gradually become a …

Poly (lactic acid)(PLA) and polyhydroxyalkanoates (PHAs), green alternatives to petroleum-based plastics: a review

AZ Naser, I Deiab, BM Darras - RSC advances, 2021 - pubs.rsc.org
In spite of the fact that petroleum-based plastics are convenient in terms of fulfilling the
performance requirements of many applications, they contribute significantly to a number of …

PEGylated lipid nanoparticle formulations: immunological safety and efficiency perspective

R Tenchov, JM Sasso, QA Zhou - Bioconjugate chemistry, 2023 - ACS Publications
Lipid nanoparticles (LNPs) have been recognized as efficient vehicles to transport a large
variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 …

Drug delivery to the central nervous system

E Nance, SH Pun, R Saigal, DL Sellers - Nature Reviews Materials, 2022 - nature.com
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

The use of alternative strategies for enhanced nanoparticle delivery to solid tumors

M Izci, C Maksoudian, BB Manshian… - Chemical …, 2021 - ACS Publications
Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

Stealth nanoparticles in oncology: Facing the PEG dilemma

S Zalba, TLM Ten Hagen, C Burgui… - Journal of Controlled …, 2022 - Elsevier
Nanoparticles (Nps) have revolutionized the landscape of many treatments, by modifying not
only pharmacokinetic properties of the encapsulated agent, but also providing a significant …

Nucleic acid delivery for therapeutic applications

A Gupta, JL Andresen, RS Manan, R Langer - Advanced Drug Delivery …, 2021 - Elsevier
Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …