Hypertension is regarded as the most prominent risk factor for cardiovascular diseases,
which have become a primary cause of death, and recent research has demonstrated that …

Abstract Purpose of Review Atherosclerosis is now considered a chronic inflammatory
disease. Oxidative stress induced by generation of excess reactive oxygen species has …

Oxidative stress has been defined as an imbalance between oxidants and antioxidants and
more recently as a disruption of redox signaling and control. It is generally accepted that …

Cardiovascular risk factors lead to enhanced production of reactive oxygen species (ROS)
generated by NADPH oxidase, xanthine oxidase (XO), the mitochondrial electron-transport …

An abnormal production of reactive oxygen species (ROS) and the subsequent decrease in
vascular bioavailability of nitric oxide (NO) have long been proposed to be the common …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is an antihypertensive,
antithrombotic and anti-atherosclerotic molecule. Hypercholesterolemia leads to a reduction …

Background We aimed to evaluate the effect of prophylactic nebivolol use on prevention of
antracycline-induced cardiotoxicity in breast cancer patients. Methods In this small …

Although reactive oxygen species (ROS) such as superoxide, hydrogen peroxide and
hydroxyl radical are generated as the natural byproduct of normal oxygen metabolism, they …

Mitochondrial metabolism has emerged as a promising target against the mechanisms of
tumor growth. Herein, we have screened an FDA-approved library to identify drugs that …