Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound
is silybin, which has a remarkable biological effect. It is used in different liver disorders …

Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key
regulatory molecules involved in cell cycle, transcription and translation, the structure of the …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

Osteosarcoma, an aggressive malignant cancer, has a high lung metastasis rate and lacks
therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed …

Wnt signaling is activated by wounding and participates in every subsequent stage of the
healing process from the control of inflammation and programmed cell death, to the …

The casein kinase 1A1 gene (CSNK1A1) is a putative tumor suppressor gene located in the
common deleted region for del (5q) myelodysplastic syndrome (MDS). We generated a …

Lung cancer is the leading cause of cancer related death, 90% of lung cancer patients die of
metastasis. Many microRNAs (miRNAs) are deregulated in cancer. They are involved in …

Melanoma progression is typically depicted as a linear and stepwise process in which
metastasis occurs relatively late in disease progression. Significant evidence suggests that …

The contribution of autophagy to cancer development remains controversial, largely owing
to the fact that autophagy can be tumour suppressive or oncogenic in different biological …

Because the Wnt/β-catenin signaling pathway is linked to melanoma pathogenesis and to
patient survival, we conducted a kinome small interfering RNA (siRNA) screen in melanoma …