Excessive adiposity raises blood pressure and accounts for 65–75% of primary
hypertension, which is a major driver of cardiovascular and kidney diseases. In obesity …

688 Hypertension October 2017 clinical patterns of HIRD susceptibility schematically
illustrated in Figure 1 with respect to the BP threshold for HIRD and the slopes of the …

Chronic Kidney Disease (CKD) is a highly prevalent disease with a substantial medical
need for new and more efficacious treatments. The Nitric Oxide (NO), soluble guanylyl …

Unilateral ischemia-reperfusion (UIR) injury leads to progressive renal atrophy and
tubulointerstitial fibrosis (TIF) and is commonly used to investigate the pathogenesis of the …

Diabetes and hypertension are the major causes of chronic kidney disease (CKD).
Epidemiological studies within the last few decades have revealed that obesity-associated …

Obesity increases the risk of renal damage, but the mechanisms are not clear. Normally,
kidneys autoregulate to keep the glomerular capillary pressure (PGC), renal blood flow, and …

Background Abnormal renal hemodynamic responses to salt‐loading are thought to
contribute to salt‐sensitive (SS) hypertension. However, this is based largely on studies in …

The relative contribution of self-perpetuating versus hemodynamic-induced fibrosis to the
progression of chronic kidney disease (CKD) after acute kidney injury (AKI) is unclear. In the …

Intrauterine growth restriction (IUGR) is, in general, accompanied by a reduction of the
nephron number, which increases the risk of hypertension and renal dysfunction. Studies …

Obesity is one of the strongest predictors of hypertension, but how obesity increases blood
pressure is currently unknown. Obesity affects the metabolism and the function of kidney …