[HTML][HTML] RNA modification in cardiovascular disease: implications for therapeutic interventions

C Wang, X Hou, Q Guan, H Zhou, L Zhou… - … and Targeted Therapy, 2023 - nature.com
Cardiovascular disease (CVD) is the leading cause of death in the world, with a high
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …

[HTML][HTML] Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease

M Jin, R Xu, L Wang, MM Alam, Z Ma, S Zhu… - Cell Stem Cell, 2022 - cell.com
Microglia are critical in brain development and Alzheimer's disease (AD) etiology. Down
syndrome (DS) is the most common genetic developmental disorder and risk factor for AD …

[HTML][HTML] The tristetraprolin family of RNA-binding proteins in cancer: progress and future prospects

Y Saini, J Chen, S Patial - Cancers, 2020 - mdpi.com
Post-transcriptional regulation of gene expression plays a key role in cellular proliferation,
differentiation, migration, and apoptosis. Increasing evidence suggests dysregulated post …

The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses

ME Cook, TR Bradstreet, AM Webber, J Kim… - Science …, 2022 - science.org
RNA binding proteins are important regulators of T cell activation, proliferation, and cytokine
production. The zinc finger protein 36 (ZFP36) family genes (Zfp36, Zfp36l1, and Zfp36l2) …

M6AREG: m6A-centered regulation of disease development and drug response

S Liu, L Chen, Y Zhang, Y Zhou, Y He… - Nucleic Acids …, 2023 - academic.oup.com
As the most prevalent internal modification in eukaryotic RNAs, N 6-methyladenosine (m6A)
has been discovered to play an essential role in cellular proliferation, metabolic …

HNRNPC downregulation inhibits IL‐6/STAT3‐mediated HCC metastasis by decreasing HIF1A expression

D Liu, X Luo, M Xie, T Zhang, X Chen, B Zhang… - Cancer …, 2022 - Wiley Online Library
RNA‐binding protein (RBP) dysregulation is functionally linked to several human diseases,
including neurological disorders, cardiovascular disease, and cancer. Heterogeneous …

[HTML][HTML] ZFP36-mediated mRNA decay regulates metabolism

AC Cicchetto, EC Jacobson, H Sunshine, BR Wilde… - Cell reports, 2023 - cell.com
Cellular metabolism is tightly regulated by growth factor signaling, which promotes
metabolic rewiring to support growth and proliferation. While growth factor-induced …

Inflammatory cytokine-regulated LNCPTCTS suppresses thyroid cancer progression via enhancing Snail nuclear export

C Ma, N Zhang, T Wang, H Guan, Y Huang, L Huang… - Cancer Letters, 2023 - Elsevier
Lymph node metastases are commonly observed in diverse malignancies where they
promote cancer progression and poor outcomes, although the molecular basis is …

Novel hypoxia-induced HIF1α-circTDRD3-positive feedback loop promotes the growth and metastasis of colorectal cancer

Z Fu, P Zhang, R Zhang, B Zhang, S Xiang, Y Zhang… - Oncogene, 2023 - nature.com
Tumor hypoxia and circular RNAs (circRNAs) are considered to play key roles in tumor
progression and malignancy, respectively. Nevertheless, the biological functions and …

[HTML][HTML] Comprehensive integrative profiling of upper tract urothelial carcinomas

X Su, X Lu, SK Bazai, E Compérat, R Mouawad, H Yao… - Genome biology, 2021 - Springer
Background Crosstalk between genetic, epigenetic, and immune alterations in upper tract
urothelial carcinomas and their role in shaping muscle invasiveness and patient outcome …