Advances in the immunology and genetics of leprosy

Z Mi, H Liu, F Zhang - Frontiers in immunology, 2020 - frontiersin.org
Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

SARS‐CoV‐2‐mediated immune system activation and potential application in immunotherapy

Y Tan, F Tang - Medicinal research reviews, 2021 - Wiley Online Library
Although novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐mediated
pulmonary inflammation has recently attracted great attention, its pathology and …

CXCL6: A potential therapeutic target for inflammation and cancer

CL Dai, HX Yang, QP Liu, K Rahman… - Clinical and Experimental …, 2023 - Springer
Chemokines were originally defined as cytokines that affect the movement of immune cells.
In recent years, due to the increasing importance of immune cells in the tumor …

Association between SNPs in microRNAs and microRNAs-machinery genes with susceptibility of leprosy in the amazon population

MNS da Silva, DF da Veiga Borges Leal… - International Journal of …, 2022 - mdpi.com
Leprosy is a chronic neurodermatological disease caused by the bacillus Mycobacterium
leprae. Recent studies show that SNPs in genes related to miRNAs have been associated …

Elevated IL-6R on CD4+ T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions

C Saini, RK Srivastava, M Tarique, S Kurra… - Scientific Reports, 2020 - nature.com
Th17 cells play vital role during pathogenesis of leprosy reactions. Previously, we have
reported that IL-23 is involved in Th17 cells differentiation. Subsequently, our group also …

Leprosy: what is new

A Randhawa, R Kapila… - International journal of …, 2022 - Wiley Online Library
Leprosy, also known as Hansen's disease, is an age‐old chronic granulomatous infection
characterized by prominent cutaneous and neurologic findings. Long known to be caused …

IL-21 plays an important role in modulating “Th17-treg” cell axis in leprosy type 1 reactions

C Saini, L Sapra, A Bhardwaj, M Tarique, A Sharma… - Cytokine, 2022 - Elsevier
Leprosy type 1 reaction (T1R) is a cell-mediated inflammatory reaction which involves skin
and peripheral nerves in leprosy. Lesions with T1R have higher production of IL-17 cytokine …

Th17 cells and cytokines in leprosy: understanding the immune response and polarization

LM Zaniolo, AS Damazo - Revista da Sociedade Brasileira de …, 2023 - SciELO Brasil
While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients
with leprosy compared with those in healthy controls, higher levels have been more evident …

Human Amniotic MSC Response in LPS-Stimulated Ascites from Patients with Cirrhosis: FOXO1 Gene and Th17 Activation in Enhanced Antibacterial Activation

M Pampalone, N Cuscino, G Iannolo, G Amico… - International Journal of …, 2024 - mdpi.com
Spontaneous bacterial peritonitis (SBP) is a severe complication in patients with
decompensated liver cirrhosis and is commonly treated with broad spectrum antibiotics …

Unveiling the role of NK cells, NKT-like cells, and γδ cells in pathogenesis of type 1 reactions in leprosy

VK Pathak, I Singh, B Sharma, RP Turankar, M Arora… - Heliyon, 2024 - cell.com
Leprosy is a disease with spectral clinical manifestations along with two types of reactions,
type 1 reaction (T1R) and type 2 reaction (T2R). T1R especially occurs because of the …