Microbial foods for improving human and planetary health

LJ Jahn, VM Rekdal, MOA Sommer - Cell, 2023 - cell.com
The current food production system is negatively impacting planetary and human health. A
transition to a sustainable and fair food system is urgently needed. Microorganisms are likely …

Cyclic di-AMP signaling in bacteria

J Stülke, L Krüger - Annual review of microbiology, 2020 - annualreviews.org
The second messenger molecule cyclic di-AMP (c-di-AMP) is formed by many bacteria and
archaea. In many species that produce c-di-AMP, this second messenger is essential for …

Improved photosynthetic capacity and photosystem I oxidation via heterologous metabolism engineering in cyanobacteria

M Santos-Merino, A Torrado… - Proceedings of the …, 2021 - National Acad Sciences
Cyanobacteria must prevent imbalances between absorbed light energy (source) and the
metabolic capacity (sink) to utilize it to protect their photosynthetic apparatus against …

Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB

KA Selim, M Haffner, M Burkhardt, O Mantovani… - Science …, 2021 - science.org
Because of their photosynthesis-dependent lifestyle, cyanobacteria evolved sophisticated
regulatory mechanisms to adapt to oscillating day-night metabolic changes. How they …

Making and breaking of an essential poison: the cyclases and phosphodiesterases that produce and degrade the essential second messenger cyclic di-AMP in …

FM Commichau, JL Heidemann, R Ficner… - Journal of …, 2019 - Am Soc Microbiol
Cyclic di-AMP is a second-messenger nucleotide that is produced by many bacteria and
some archaea. Recent work has shown that c-di-AMP is unique among the signaling …

The circadian clock and darkness control natural competence in cyanobacteria

A Taton, C Erikson, Y Yang, BE Rubin, SA Rifkin… - Nature …, 2020 - nature.com
The cyanobacterium Synechococcus elongatus is a model organism for the study of
circadian rhythms. It is naturally competent for transformation—that is, it takes up DNA from …

A hard day's night: cyanobacteria in diel cycles

DG Welkie, BE Rubin, S Diamond, RD Hood… - Trends in …, 2019 - cell.com
Cyanobacteria are photosynthetic prokaryotes that are influential in global geochemistry and
are promising candidates for industrial applications. Because the livelihood of cyanobacteria …

A decade of research on the second messenger c-di-AMP

W Yin, X Cai, H Ma, L Zhu, Y Zhang… - FEMS microbiology …, 2020 - academic.oup.com
ABSTRACT Cyclic dimeric adenosine 3′, 5′-monophosphate (c-di-AMP) is an emerging
second messenger in bacteria and archaea that is synthesized from two molecules of ATP …

Cyclic di-AMP, a second messenger of primary importance: tertiary structures and binding mechanisms

J He, W Yin, MY Galperin, SH Chou - Nucleic acids research, 2020 - academic.oup.com
Cyclic diadenylate (c-di-AMP) is a widespread second messenger in bacteria and archaea
that is involved in the maintenance of osmotic pressure, response to DNA damage, and …

Gene regulation and transcriptomics

DS Samuels, MC Lybecker, XF Yang, Z Ouyang… - Current issues in …, 2021 - mdpi.com
Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …