Multiple osteochondromas is an autosomal dominant skeletal disorder characterized by the
formation of multiple cartilage-capped tumours. Two causal genes have been identified …

Genome-wide association studies have proven to be highly effective at defining
relationships between single nucleotide polymorphisms (SNPs) and clinical phenotypes in …

Background Multiple osteochondromas is a dysplasia characterized by growth of two or
more osteochondromas. It is genetically heterogeneous, caused by pathogenic variants in …

Multiple Osteochondromatosis (MO, MIM 133700 & 133701), an autosomal dominant O-
glycosylation disorder (EXT1/EXT2-CDG), can be associated with a reduction in skeletal …

Heparan sulfate (HS) is recognized as an important player in a wide range of dynamic steps
of inflammatory reactions. Thereby, structural HS remodeling is likely to play an important …

Multiple osteochondromatosis (MO), or EXT1/EXT2-CDG, is an autosomal dominant O-
linked glycosylation disorder characterized by the formation of multiple cartilage-capped …

Abstract Exostosin-1 (EXT1) has been demonstrated to participate in the progression of
many cancers. However, it has not been previously described in patients with hepatocellular …

Background Helicobacter pylori (H. pylori) infects nearly half of the world's population with a
variation in incidence among different geographic regions. Genetic variants in the promoter …

Multiple osteochondromas (MO) is an autosomal dominant hereditary disorder caused by
heterozygous germline mutations in the exostonsin‐1 (EXT1) or exostosin‐2 (EXT2) genes …

Background: Multiple osteochondroma (MO), an autosomal dominant genetic disease, is
caused by heterozygous mutations in the EXT1 and EXT2 genes. Approximately 80% of …