Applying an evolutionary mismatch framework to understand disease susceptibility

AJ Lea, AG Clark, AW Dahl, O Devinsky, AR Garcia… - PLoS …, 2023 - journals.plos.org
Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular
disease, and type 2 diabetes are among a long list of “lifestyle” diseases that were rare …

Health disparities among Indigenous peoples: exploring the roles of evolutionary and developmental mismatch on cardiometabolic health

M Gurven, A Sarrieddine, A Lea - Annual Review of …, 2024 - annualreviews.org
The health of Indigenous populations suffers compared with that of non-Indigenous
neighbors in every country. Although health deficits have long been recognized, remedies …

Dietary stress remodels the genetic architecture of lifespan variation in outbred Drosophila

LF Pallares, AJ Lea, C Han, EV Filippova… - Nature …, 2023 - nature.com
Evolutionary theory suggests that lifespan-reducing alleles should be purged from the gene
pool, and yet decades of genome-wide association and model organism studies have …

Factors influencing migration and settlement of pastoralists in Nairobi City, Kenya

WM Wafula, OV Wasonga, OK Koech, S Kibet - Pastoralism, 2022 - Springer
Pastoralism is globally recognized as the backbone of the economy in the vast arid and semi-
arid rangelands. Despite its enormous economic contribution, the system is facing a myriad …

Drinking water salinity is associated with hypertension and hyperdilute urine among Daasanach pastoralists in Northern Kenya

AY Rosinger, H Bethancourt, ZS Swanson… - Science of the Total …, 2021 - Elsevier
Water salinity is a growing global environmental health concern. However, little is known
about the relation between water salinity and chronic health outcomes in non-coastal, lean …

Wild capuchin monkeys as a model system for investigating the social and ecological determinants of ageing

FA Campos, EC Wikberg, JD Orkin… - Philosophical …, 2024 - royalsocietypublishing.org
Studying biological ageing in animal models can circumvent some of the confounds
exhibited by studies of human ageing. Ageing research in non-human primates has …

Can circadian eating pattern adjustments reduce risk or prevent development of T2D?

C Harris, K Czaja - Nutrients, 2023 - mdpi.com
Type 2 diabetes (T2D) is a chronic condition that occurs in insulin-resistant people with
reduced glucose uptake. It is contributed to and exacerbated by a poor diet that results in …

The Influence of New-Type Urbanization and Environmental Pollution on Public Health: A Spatial Durbin Model Study

K Wu, R Wang, Y Zhang, R Wu, Y He, B Li, Y Zhang - Sustainability, 2023 - mdpi.com
The rapid pace of urbanization in recent years, accompanied by the tension between
urbanization and environmental pollution as well as public health, has become increasingly …

Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model

CSC Johnson, CA Shively, KT Michalson, AJ Lea… - Elife, 2021 - elifesciences.org
Dietary changes associated with industrialization increase the prevalence of chronic
diseases, such as obesity, type II diabetes, and cardiovascular disease. This relationship is …

Mountains of research: Where and whom high‐altitude physiology has overlooked

JC Tremblay - The Journal of Physiology, 2024 - Wiley Online Library
High altitude is a natural setting in which to study human acclimatization and adaptation.
Here, I identify where and in whom high‐altitude physiology research has occurred. There …