Mitochondrial-derived vesicles in metabolism, disease, and aging

T König, HM McBride - Cell Metabolism, 2024 - cell.com
Mitochondria are central hubs of cellular metabolism and are tightly connected to signaling
pathways. The dynamic plasticity of mitochondria to fuse, divide, and contact other …

[HTML][HTML] Mitochondria on the move: Horizontal mitochondrial transfer in disease and health

LF Dong, J Rohlena, R Zobalova, Z Nahacka… - Journal of Cell …, 2023 - rupress.org
Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control

T König, H Nolte, MJ Aaltonen, T Tatsuta, M Krols… - Nature cell …, 2021 - nature.com
Mitochondrial-derived vesicles (MDVs) are implicated in diverse physiological processes—
for example, mitochondrial quality control—and are linked to various neurodegenerative …

VPS13D bridges the ER to mitochondria and peroxisomes via Miro

A Guillén-Samander, M Leonzino, MG Hanna IV… - Journal of Cell …, 2021 - rupress.org
Mitochondria, which are excluded from the secretory pathway, depend on lipid transport
proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the …

Miro proteins coordinate microtubule‐and actin‐dependent mitochondrial transport and distribution

G López‐Doménech, C Covill‐Cooke… - The EMBO …, 2018 - embopress.org
In the current model of mitochondrial trafficking, Miro1 and Miro2 Rho‐GTP ases regulate
mitochondrial transport along microtubules by linking mitochondria to kinesin and dynein …

Fueling the cell division cycle

M Salazar-Roa, M Malumbres - Trends in cell biology, 2017 - cell.com
Cell division is a complex process with high energy demands. However, how cells regulate
the generation of energy required for DNA synthesis and chromosome segregation is not …

Nuclear-mitochondrial interactions

BR Walker, CT Moraes - Biomolecules, 2022 - mdpi.com
Mitochondria, the cell's major energy producers, also act as signaling hubs, interacting with
other organelles both directly and indirectly. Despite having its own circular genome, the …

Motor proteins at the mitochondria–cytoskeleton interface

AJ Kruppa, F Buss - Journal of cell science, 2021 - journals.biologists.com
Mitochondria are multifunctional organelles that not only produce energy for the cell, but are
also important for cell signalling, apoptosis and many biosynthetic pathways. In most cell …

Regulation of mitochondrial structure and dynamics by the cytoskeleton and mechanical factors

E Bartolák-Suki, J Imsirovic, Y Nishibori… - International journal of …, 2017 - mdpi.com
Mitochondria supply cells with energy in the form of ATP, guide apoptosis, and contribute to
calcium buffering and reactive oxygen species production. To support these diverse …

Mechanical force induces mitochondrial fission

SCJ Helle, Q Feng, MJ Aebersold, L Hirt, RR Grüter… - Elife, 2017 - elifesciences.org
Eukaryotic cells are densely packed with macromolecular complexes and intertwining
organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing …