Statins: Adverse reactions, oxidative stress and metabolic interactions

A Liu, Q Wu, J Guo, I Ares, JL Rodríguez… - Pharmacology & …, 2019 - Elsevier
Abstract Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are currently
the most effective lipid-lowering drugs, effectively reducing the plasma total cholesterol and …

Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials

M Banach, C Serban, A Sahebkar, S Ursoniu… - Mayo Clinic …, 2015 - Elsevier
Objective To evaluate the efficacy of coenzyme Q10 (CoQ10) supplementation on statin-
induced myopathy. Participants and Methods We searched the MEDLINE, Cochrane Library …

Statins in therapy: Cellular transport, side effects, drug-drug interactions and cytotoxicity-the unrecognized role of lactones

CW Fong - 2016 - hal.science
Abbreviations: drug-drug interactions (DDI), human serum albumin (HSA), area under the
curve fold ratio (AUCR), free energy change (ΔG), electron affinity (EA), reactive oxygen …

[PDF][PDF] Molecular mechanisms of statin intolerance

A Gluba-Brzozka, B Franczyk, P Toth, J Rysz… - Archives of Medical …, 2016 - termedia.pl
Statins reduce cardiovascular morbidity and mortality in primary and secondary prevention.
Despite their efficacy, many persons are unable to tolerate statins due to adverse events …

Coenzyme Q10 prevents mitochondrial dysfunction and facilitates pharmacological activity of atorvastatin in 6-OHDA induced dopaminergic toxicity in rats

SK Prajapati, D Garabadu, S Krishnamurthy - Neurotoxicity research, 2017 - Springer
Atorvastatin (ATV) generally used to treat dyslipidemia is also reported to have effect against
6-hydroxydopamine (6-OHDA) induced neurotoxicity. Additionally, atorvastatin can interfere …

CoQ10 deficiency may indicate mitochondrial dysfunction in Cr (VI) toxicity

X Zhong, X Yi, RDC Da Silveira e Sá, Y Zhang… - International Journal of …, 2017 - mdpi.com
To investigate the toxic mechanism of hexavalent chromium Cr (VI) and search for an
antidote for Cr (VI)-induced cytotoxicity, a study of mitochondrial dysfunction induced by Cr …

Coenzyme Q10 or creatine counteract pravastatin-induced liver redox changes in hypercholesterolemic mice

AC Marques, ENB Busanello, DN De Oliveira… - Frontiers in …, 2018 - frontiersin.org
Statins are the preferred therapy to treat hypercholesterolemia. Their main action consists of
inhibiting the cholesterol biosynthesis pathway. Previous studies report mitochondrial …

[HTML][HTML] Cytoprotective effects of melatonin against amitriptyline-induced toxicity in isolated rat hepatocytes

S Taziki, MR Sattari, S Dastmalchi… - Advanced …, 2015 - ncbi.nlm.nih.gov
Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but
severe hepatotoxicity in patients who received it continuously. Previous findings showed that …

[HTML][HTML] Основные побочные эффекты статинов в клинической практике

АМ Чаулин - Клиническая практика, 2022 - cyberleninka.ru
Статины уже давно занимают центральное место в сердечно-сосудистой медицине,
являясь неотъемлемым компонентом профилактики и лечения атеросклеротических …

The effects of simvastatin and fenofibrate on malondialdehyde and reduced glutathione concentrations in the plasma, liver, and brain of normolipidaemic and …

A Vukšić, D Rašić, S Žunec, T Božina… - Archives of Industrial …, 2023 - sciendo.com
Cilj ovog istraživanja bio je istražiti učinke različitih doza simvastatina i fenofibrata na
malondialdehid (MDA) i reducirani glutation (GSH) u plazmi, jetri i mozgu mužjaka …