Increasing evidences point to G protein-coupled receptor kinases (GRKs), a subfamily of
protein kinase A/G/C-like kinases, as relevant players in cancer progression, in a cell-type …

The development of small-molecule inhibitors targeting G protein-coupled receptor kinase 2
(GRK2) and G protein-coupled receptor kinase 5 (GRK5) for the treatment of chronic …

Malignant features—such as sustained proliferation, refractoriness to growth suppressors,
resistance to cell death or aberrant motility, and metastasis—can be triggered by a variety of …

Simple Summary Epithelioid haemangioendothelioma (EHE) is an ultra-rare malignant
vascular tumour with a prevalence of 1 per 1,000,000. It develops from endothelial cells …

Background Colorectal cancer (CRC) is a malignant tumor of the gastrointestinal tract with
high morbidity and mortality. There is growing evidence that GRK2 plays a key role in the …

Simple Summary The involvement of GRK2 in cancer growth and an inverse correlation with
p53 levels were suggested in breast cancer. Furthermore, increased GRK2 expression and …

TNF-α has been confirmed to promote tumor growth in LSCC. PGE2 expression in LSCC
tissues was significantly higher than in tumor-adjacent tissues. In the present work, we …

Background: Epithelioid haemangioendothelioma (EHE) is an ultra-rare malignant vascular
tumour with a prevalence of 1 per 1,000,000. It is typically molecularly characterised by a …

Malignant features such as sustained proliferation, refractoriness to growth suppressors,
resistance to cell death or aberrant motility and metastasis can be triggered by a variety of …

16: 30-16: 45 Davide Cirillo (BSC). Training IBM Watson with MelanomaMine. 16: 45-17: 00
Renée Beekman (IDIBAPS). Integration of genomic and epigenomic data, including the …