Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological
conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating …

The epilepsies are a heterogeneous group of disorders characterized by the propensity to
experience spontaneous recurrent seizures. Epilepsies can be genetic or acquired, and the …

An insult to the brain (such as the first seizure) causes excitotoxicity, neuroinflammation, and
production of reactive oxygen/nitrogen species (ROS/RNS). ROS and RNS produced during …

Mitofilin proteins are crucial organizers of mitochondrial architecture. They are located in the
inner mitochondrial membrane and interact with several protein complexes of the outer …

Background Oxidative stress plays an important role in the pathology of ischemic stroke.
Studies have confirmedthat scutellarin has antioxidant effects against ischemic injury, and …

Antiepileptic drug therapy, though beneficial for restraining seizures, cannot thwart status
epilepticus (SE) induced neurodegeneration or down-stream detrimental changes. We …

Mitochondria perform a plethora of functions in various cells of different tissues. Their
architecture differs remarkably, for instance in neurons versus steroidogenic cells …

Mitofilin, also known as heart muscle protein, is an inner mitochondrial membrane structural
protein that plays a central role in maintaining cristae morphology and structure. It is a critical …

Nox generated ROS, particularly those derived from Nox1, Nox2 and Nox4, have emerged
as important regulators of the actin cytoskeleton and cytoskeleton-supported cell functions …

The ancient Greeks attributed life to Mother Nature, complaining that she was fond of hiding
the workings of her creations. Although we no longer attribute the mysteries of life to Mother …