Particles capable of homing and adhering to specific vascular biomarkers have potential as fundamental tools in drug delivery for mediation of a wide variety of pathologies, including …
MJ Paszek, D Boettiger, VM Weaver… - PLoS computational …, 2009 - journals.plos.org
Integrins have emerged as key sensory molecules that translate chemical and physical cues from the extracellular matrix (ECM) into biochemical signals that regulate cell behavior …
ER Cruz-Chu, A Malafeev, T Pajarskas, IV Pivkin… - Biophysical journal, 2014 - cell.com
The glycocalyx is a sugar-rich layer located at the luminal part of the endothelial cells. It is involved in key metabolic processes and its malfunction is related to several diseases. To …
J Liu, GER Weller, B Zern… - Proceedings of the …, 2010 - National Acad Sciences
A computational methodology based on Metropolis Monte Carlo (MC) and the weighted histogram analysis method (WHAM) has been developed to calculate the absolute binding …
Targeting nanoparticles (NPs) loaded with drugs and probes to precise locations in the body may improve the treatment and detection of many diseases. Generally, to achieve targeting …
GM Pavan, A Danani, S Pricl… - Journal of the American …, 2009 - ACS Publications
This paper reports the application of molecular dynamics methods to understand the interactions between dendritic molecules with spermine surface groups and double-helical …
S Akbarishandiz, S Khani, J Maia - Soft Matter, 2023 - pubs.rsc.org
Targeted drug delivery to endothelial cells utilizing functionalized nanocarriers (NCs) is an essential procedure in therapeutic and diagnosis therapies. Using dissipative particle …
M McKenzie, SM Ha, A Rammohan… - Biophysical …, 2018 - cell.com
We utilize a multiscale modeling framework to study the effect of shape, size, and ligand composition on the efficacy of binding of a ligand-coated particle to a substrate …
The endothelial glycocalyx (EG), a sugar-rich layer that lines the luminal surface of blood vessels, is an important constituent of the vascular system. Although the chemical …