Targeted delivery of therapeutics to endothelium

E Simone, BS Ding, V Muzykantov - Cell and tissue research, 2009 - Springer
The endothelium is a target for therapeutic and diagnostic interventions in a plethora of
human disease conditions including ischemia, inflammation, edema, oxidative stress …

Non-affinity factors modulating vascular targeting of nano-and microcarriers

JW Myerson, AC Anselmo, Y Liu, S Mitragotri… - Advanced drug delivery …, 2016 - Elsevier
Particles capable of homing and adhering to specific vascular biomarkers have potential as
fundamental tools in drug delivery for mediation of a wide variety of pathologies, including …

Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate

MJ Paszek, D Boettiger, VM Weaver… - PLoS computational …, 2009 - journals.plos.org
Integrins have emerged as key sensory molecules that translate chemical and physical cues
from the extracellular matrix (ECM) into biochemical signals that regulate cell behavior …

Structure and response to flow of the glycocalyx layer

ER Cruz-Chu, A Malafeev, T Pajarskas, IV Pivkin… - Biophysical journal, 2014 - cell.com
The glycocalyx is a sugar-rich layer located at the luminal part of the endothelial cells. It is
involved in key metabolic processes and its malfunction is related to several diseases. To …

Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments

J Liu, GER Weller, B Zern… - Proceedings of the …, 2010 - National Acad Sciences
A computational methodology based on Metropolis Monte Carlo (MC) and the weighted
histogram analysis method (WHAM) has been developed to calculate the absolute binding …

Reduction of nanoparticle avidity enhances the selectivity of vascular targeting and PET detection of pulmonary inflammation

BJ Zern, AM Chacko, J Liu, CF Greineder… - ACS …, 2013 - ACS Publications
Targeting nanoparticles (NPs) loaded with drugs and probes to precise locations in the body
may improve the treatment and detection of many diseases. Generally, to achieve targeting …

Modeling the multivalent recognition between dendritic molecules and DNA: understanding how ligand “sacrifice” and screening can enhance binding

GM Pavan, A Danani, S Pricl… - Journal of the American …, 2009 - ACS Publications
This paper reports the application of molecular dynamics methods to understand the
interactions between dendritic molecules with spermine surface groups and double-helical …

Adhesion dynamics of functionalized nanocarriers to endothelial cells: a dissipative particle dynamics study

S Akbarishandiz, S Khani, J Maia - Soft Matter, 2023 - pubs.rsc.org
Targeted drug delivery to endothelial cells utilizing functionalized nanocarriers (NCs) is an
essential procedure in therapeutic and diagnosis therapies. Using dissipative particle …

Multivalent binding of a ligand-coated particle: role of shape, size, and ligand heterogeneity

M McKenzie, SM Ha, A Rammohan… - Biophysical …, 2018 - cell.com
We utilize a multiscale modeling framework to study the effect of shape, size, and ligand
composition on the efficacy of binding of a ligand-coated particle to a substrate …

Structure and elasticity of bush and brush-like models of the endothelial glycocalyx

A Kabedev, V Lobaskin - Scientific Reports, 2018 - nature.com
The endothelial glycocalyx (EG), a sugar-rich layer that lines the luminal surface of blood
vessels, is an important constituent of the vascular system. Although the chemical …