Imaging the evolution and pathophysiology of Alzheimer disease

W Jagust - Nature Reviews Neuroscience, 2018 - nature.com
Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

Emerging concepts in sporadic cerebral amyloid angiopathy

A Charidimou, G Boulouis, ME Gurol, C Ayata… - Brain, 2017 - academic.oup.com
Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and
a largely untreatable cause of intracerebral haemorrhage and contributor to age-related …

White matter hyperintensities are a core feature of Alzheimer's disease: evidence from the dominantly inherited Alzheimer network

S Lee, F Viqar, ME Zimmerman, A Narkhede… - Annals of …, 2016 - Wiley Online Library
Objective White matter hyperintensities (WMHs) are areas of increased signal on T2‐
weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel …

Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions

A Charidimou, J Linn, MW Vernooij, C Opherk… - Brain, 2015 - academic.oup.com
Cortical superficial siderosis describes a distinct pattern of blood-breakdown product
deposition limited to cortical sulci over the convexities of the cerebral hemispheres, sparing …

[PDF][PDF] Cerebral amyloid angiopathy: emerging concepts

M Yamada - Journal of stroke, 2015 - synapse.koreamed.org
Cerebral amyloid angiopathy (CAA) involves cerebrovascular amyloid deposition and is
classified into several types according to the amyloid protein involved. Of these, sporadic …

MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy

A Charidimou, G Boulouis, M Pasi, E Auriel… - Neurology, 2017 - AAN Enterprises
Objective: To assess MRI-visible enlarged perivascular spaces (EPVS) burden and different
topographical patterns (in the centrum semiovale [CSO] and basal ganglia [BG]) in 2 …

White matter hyperintensities: relationship to amyloid and tau burden

J Graff-Radford, EM Arenaza-Urquijo, DS Knopman… - Brain, 2019 - academic.oup.com
Although white matter hyperintensities have traditionally been viewed as a marker of
vascular disease, recent pathology studies have found an association between white matter …

Validation of clinicoradiological criteria for the diagnosis of cerebral amyloid angiopathy–related inflammation

E Auriel, A Charidimou, ME Gurol, J Ni… - JAMA …, 2016 - jamanetwork.com
Importance Cerebral amyloid angiopathy–related inflammation (CAA-ri) is an important
diagnosis to reach in clinical practice because many patients with the disease respond to …

Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly

P Vemuri, TG Lesnick, SA Przybelski, DS Knopman… - Brain, 2015 - academic.oup.com
Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …

White matter hyperintensity patterns in cerebral amyloid angiopathy and hypertensive arteriopathy

A Charidimou, G Boulouis, K Haley, E Auriel… - Neurology, 2016 - AAN Enterprises
Objective: To identify different white matter hyperintensity (WMH) patterns between 2
hemorrhage-prone cerebral small vessel diseases (SVD): cerebral amyloid angiopathy …