Nutrigenomics describes the interaction between nutrients and our genome. Since the origin
of our species most of these nutrient-gene communication pathways have not changed …

Background Understanding the health consequences associated with exposure to risk
factors is necessary to inform public health policy and practice. To systematically quantify the …

Diabetic kidney disease (DKD) is a severe diabetic complication that affects up to half of the
individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD …

• FinRegistry is a curated, nationwide, register-based data resource for developing statistical
and machine learning models, performing high-throughput epidemiological analyses and …

Polygenic scores (PGSs) offer the ability to predict genetic risk for complex diseases across
the life course; a key benefit over short-term prediction models. To produce risk estimates …

The multiple comorbidities & dimensions of chronic pain present a formidable challenge in
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …

IL-6 mediated inflammation most likely causes ASCVD, in parallel with LDL cholesterol.
However, fewer individuals in the general population are exposed to high IL-6 than high …

Physical activity (PA), aerobic fitness, and cardiometabolic diseases (CMD) are highly
heritable multifactorial phenotypes. Shared genetic factors may underlie the associations …

Aging is a major risk factor for vascular disease. Increased levels of milk fat globule-EGF
factor 8 (MFG-E8) are associated with many age-related arterial changes, but the …

Rare damaging variants in a large number of genes are known to cause monogenic
developmental disorders (DDs) and have also been shown to cause milder subclinical …