Cryogenic electron microscopy (cryo-EM) enables structure determination of
macromolecular objects and their assemblies. Although the techniques have been …

Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …

PIEZO channels respond to piconewton-scale forces to mediate critical physiological and
pathophysiological processes,,,–. Detergent-solubilized PIEZO channels form bowl-shaped …

Influenza vaccines that confer broad and durable protection against diverse viral strains
would have a major effect on global health, as they would lessen the need for annual …

The tremendous pandemic potential of coronaviruses was demonstrated twice in the past
few decades by two global outbreaks of deadly pneumonia. The coronavirus spike (S) …

Respiratory syncytial virus (RSV) is a worldwide public health concern for which no vaccine
is available. Elucidation of the prefusion structure of the RSV F glycoprotein and its …

Cryo-electron microscopy (cryo-EM) is rapidly becoming an attractive method in the field of
structural biology. With the exploding popularity of cryo-EM, sample preparation must evolve …

Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural
determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins …

CRISPR-Cas endonucleases directed against foreign nucleic acids mediate prokaryotic
adaptive immunity and have been tailored for broad genetic engineering applications. Type …

Membrane proteins (MPs) used to be the most difficult targets for structural biology when X-
ray crystallography was the mainstream approach. With the resolution revolution of single …