In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

The divergent supramolecular behavior of a series of tripeptide stereoisomers was
elucidated through spectroscopic, microscopic, crystallographic, and computational …

The pK a values of functional groups is crucial in determining the pharmacokinetic
properties of a drug, affecting its absorption and thus bioavailability. This physicochemical …

Objective Glycation is a non-enzymatic and spontaneous post-translational modification
(PTM) generated by the reaction between reducing sugars and primary amine groups within …

Peptides are small polymers composed of 40 or fewer amino acids and are an increasingly
important class of drugs. Therapeutic peptides are less immunogenic and more economical …

The α-Gal epitope consisting of the terminal trisaccharide Galα1, 3Galβ1, 4GlcNAc exposed
on cell or protein surfaces can cause severe immune reactions, such as hypersensitivity …

In humans, age-associated degrading changes, widely observed in molecular and cellular
processes underly the time-dependent decline in spatial navigation, time perception …

Posttranslational modifications (PTMs) play vital roles in cellular homeostasis and are
implicated in various pathological conditions. This work uses two ion mobility spectrometry …

Short peptides containing the Arg-Gly-Asp (RGD) fragment can selectively bind to integrins
on the surface of tumor cells and are attractive transport molecules for the targeted delivery …