P2X1: a unique platelet receptor with a key role in thromboinflammation

C Oury, O Wéra - Platelets, 2021 - Taylor & Francis
Thromboinflammation involves complex interactions between actors of inflammation and
immunity and components of the hemostatic system, which are elicited upon infection or …

Physiologic roles of P2 receptors in leukocytes

AVP Alberto, NC da Silva Ferreira… - Journal of Leukocyte …, 2022 - academic.oup.com
Since their discovery in the 1970s, purinergic receptors have been shown to play key roles
in a wide variety of biologic systems and cell types. In the immune system, purinergic …

Functional expression of P2X1, P2X4 and P2X7 purinergic receptors in human monocyte-derived macrophages

EM Vargas-Martinez, KS Gomez-Coronado… - European journal of …, 2020 - Elsevier
This study sought to examine the co-expression of the following purinergic receptor
subunits: P2X1, P2X1del, P2X4, and P2X7 and characterize the P2X response in human …

Methylomic and transcriptomic characterization of postoperative systemic inflammatory dysregulation

CR Bain, PS Myles, R Taylor, H Trahair, YP Lee… - Translational …, 2022 - Elsevier
In this study, we define and validate a state of postoperative systemic inflammatory
dysregulation (PSID) based on postoperative phenotypic extremes of plasma C-reactive …

[HTML][HTML] Dynamical changes in the expression of GABAergic and purinergic components occur during the polarization of THP-1 monocytes to proinflammatory …

VM Ruiz-Rodríguez, CA Torres-González… - … and Biophysics Reports, 2023 - Elsevier
The monocytes are key components of innate immunity, as they can differentiate into
phagocytic cells or macrophages with proinflammatory or anti-inflammatory phenotypes. The …

Purinergic receptors: elucidating the role of these immune mediators in HIV-1 fusion

TL Freeman, TH Swartz - Viruses, 2020 - mdpi.com
Purinergic receptors are inflammatory mediators activated by extracellular nucleotides
released by dying or injured cells. Several studies have described an important role for …

The ATP-gated P2X1 ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice

MB El Mdawar, B Maître, S Magnenat, C Gachet… - Scientific Reports, 2019 - nature.com
The biological responses that control the development of Transfusion-Related Acute Lung
Injury (TRALI), a serious post-transfusion respiratory syndrome, still need to be clarified …

Physiological concentrations of zinc have dual effects on P2X myenteric receptors of Guinea pig

LH Méndez-Barredo, JG Rodríguez-Meléndez… - Cellular and Molecular …, 2018 - Springer
We, hereby, characterize the pharmacological effects of physiological concentrations of Zinc
on native myenteric P2X receptors from guinea-pig small intestine and on P2X2 isoforms …

Identificación de los sitios de unión al ATP en receptores P2X1 de humanos.

E Tejeda Jaramillo - 2018 - repositorio.ipicyt.edu.mx
" Los receptores P2X son canales catiónicos no selectivos activados por trifosfato de
adenosina (ATP), involucrados en diversos procesos fisiológicos como neurotransmisión …

Caracterización electrofisiológica de receptores hP2X1 y hP2X1del coexpresados en ovocitos de Xenopus laevis

KS Gómez Coronado - 2018 - repositorio.ipicyt.edu.mx
" Human leukocytes release nucleotides, including ATP, bind to purinergic receptors to
trigger a number of cellular process, such as the death of pathogens. The understanding of …