As synaptic vesicles fuse, they must continually be replaced with new docked, fusion-
competent vesicles to sustain neurotransmission. It has long been appreciated that vesicles …

Sustained neuronal activity demands a rapid resupply of synaptic vesicles to maintain
reliable synaptic transmission. Such vesicle replenishment is accelerated by submicromolar …

Synapses with high release probability (Pr) tend to exhibit short-term synaptic depression.
According to the prevailing model, this reflects the temporary depletion of release-ready …

Neurotransmitter release consists of rapid synchronous release followed by longer-lasting
asynchronous release (AR). Although the presynaptic proteins that trigger synchronous …

Fragile X syndrome (FXS) is an intellectual developmental disorder characterized, inter alia,
by deficits in the short-term processing of neural information, such as sensory processing …

Immunofluorescent labeling revealed calmodulin, Ca2+/calmodulin-dependent protein
kinases I and II, synaptotagmin II and VII, and calcineurin A in somatic motor muscles of the …

Neurotransmitter is released from dedicated sites of synaptic vesicle fusion within a
synapse. Following fusion, vacated sites are rapidly replenished by new vesicles. These …