The inherent stochasticity in the gene product levels can drive single cells within an
isoclonal population to different phenotypic states. The dynamic nature of this intercellular …

Cell-to-cell variability of infection has long been known, yet it has remained one of the least
understood phenomena in infection research. It impacts on disease onset and development …

Abstract Type I interferon (IFN-I)-mediated antiviral responses are central to host defense
against viral infections. Crucial is the tight and well-orchestrated control of cellular decision …

Viruses display large variability across all stages of their life cycle, including entry, gene
expression, replication, assembly, and egress. We previously reported that the immediate …

Assigning single cell transcriptomes to cellular lineage trees by lineage tracing has
transformed our understanding of differentiation during development, regeneration, and …

In the noisy cellular environment, RNAs and proteins are subject to considerable stochastic
fluctuations in copy numbers over time. As a consequence, single cells within the same …

Clonal populations of microbial and cancer cells are often driven into a drug-tolerant
persister state in response to drug therapy, and these persisters can subsequently adapt to …

The integration of lineage tracing with scRNA-seq has transformed our understanding of
gene expression heritability during development, regeneration, and disease. However …

Moving from the optimalization of single‐cell technologies to the interpretation of the multi‐
complex single‐cell data, the field of immunoengineering is granted with numerous …

In the noisy cellular environment, RNAs and proteins are subject to considerable stochastic
fluctuations in copy numbers over time. As a consequence, single cells within the same …