In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

One of the hallmarks of Alzheimer's disease (AD) is structural cell damage and neuronal
death in the brains of affected individuals. As these changes are irreversible, it is important …

An early disruption of neuronal excitation–inhibition (E–I) balance in preclinical animal
models of Alzheimer's disease (AD) has been frequently reported, but is difficult to measure …

Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
decline. These impairments correlate with early alterations in neuronal network activity in AD …

Current methods for recording large-scale neuronal activity from behaving mice at single-
cell resolution require either fixing the mouse head under a microscope or attachment of a …

The early stages of Alzheimer's disease (AD) have been linked to microcircuit dysfunction
and pathophysiological neuronal firing in several brain regions. Inhibitory GABAergic …

Acetylcholine is released in visual cortex by axonal projections from the basal forebrain. The
signals conveyed by these projections and their computational significance are still unclear …

Multiscale neurophysiology reveals that simple motor actions are associated with changes
in neuronal firing in virtually every brain region studied. Accordingly, the assessment of focal …

Neuronal dysfunction in specific brain regions or across distributed brain networks is a
known feature of Alzheimer's disease. An often reported finding in the early stage of the …

Cranial window surgery allows for the imaging of brain tissue in live mice with the use of
multiphoton or other intravital imaging techniques. However, when performing any …