Background The interplay between cancer cells and stromal components, including soluble
mediators released from cancer cells, contributes to the progression of pancreatic ductal …

Oxidative stress contributes to the pathophysiology of a variety of diseases, and circulating
biomarkers of its severity remains a topic of great interest for researchers. Our peptidomic …

With the combination of different mechanisms, two-dimensional liquid chromatography has
brought revolutionary changes compared to the traditional one-dimensional separation …

Protein and RNA profiles are highly informative when generating a comprehensive
understanding of the dynamics of complex biological systems. Quantitative correlations …

Identification of low-abundance, low-molecular-weight native peptides using non-tryptic
plasma has long remained an unmet challenge, leaving potential bioactive/biomarker …

The discovery of bioactive peptides is an important research target that enables the
elucidation of the pathophysiology of human diseases and provides seeds for drug …

Salusin-β is an endogenous parasympathomimetic proatherosclerotic peptide. Salusin-β
was initially predicted from bioinformatic analyses and later immunologically detected in …

Background Fibrinogen alpha C chain 5.9 kDa fragment (FIC5. 9) is a new serum biomarker
for chronic hepatitis that was discovered by proteomics analysis. Previous studies have …

Background Acute mesenteric ischemia (AMI) is challenging to diagnose in the early phase.
We tested the hypothesis that blood levels of cell-free DNA would increase early after AMI. In …

Results selection of serum tryptic peptides containing an oxidized methionine. Because Met
residues are reportedly vulnerable to oxidation in many experimental settings, we first …