Chronic neuroinflammation serves a key role in the onset and progression of
neurodegenerative disorders. Mitochondria serve as central regulators of …

Neurodegenerative diseases represent a significant challenge to modern medicine, with
their complex etiology and progressive nature posing hurdles to effective treatment …

Mitochondrial quality control failure is frequently observed in neurodegenerative diseases.
The detection of damaged mitochondria by stabilization of PTEN-induced kinase 1 (PINK1) …

Parkinson's disease (PD) is a chronic, neurodegenerative condition characterized by motor
symptoms such as bradykinesia, rigidity, and tremor, alongside multiple nonmotor …

MATERIALS AND METHODS: The hiPSCs cell line was procured from a commercial source,
grown, and characterized following standard protocols. The mutation in hiPSCs was …

Oxidative stress-mediated damage is often a downstream result of Parkinson's disease (PD),
which is marked by sharp decline in dopaminergic neurons within the nigrostriatal regions of …

Alpha-synuclein's role in diseases termed “synucleinopathies”, including Parkinson's
disease, has been well-documented. However, after over 25 years of research, we still do …

Prolonged manganese exposure causes manganism, a neurodegenerative movement
disorder. The identity of adaptive and nonadaptive cellular processes targeted by …

Parkinson's disease (PD) is the second most common neurodegenerative disorder. The
exact molecular mechanism of disease remains unclear. Several factors are proposed to …

INTRODUCTION: Biallelic loss-of-function mutations in DNAJC6 cause a complex early-
onset neurodegenerative condition characterised by juvenile-onset parkinsonism-dystonia …